Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1438521..1439168 Replicon chromosome
Accession NC_023032
Organism Cronobacter sakazakii CMCC 45402

Toxin (Protein)


Gene name higB Uniprot ID V5TX81
Locus tag P262_RS06820 Protein ID WP_007776552.1
Coordinates 1438521..1438868 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID V5TYW5
Locus tag P262_RS06825 Protein ID WP_007776551.1
Coordinates 1438869..1439168 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P262_RS06795 1434096..1435106 + 1011 WP_004387466.1 galactose/methyl galactoside ABC transporter permease MglC -
P262_RS06800 1435322..1436035 - 714 WP_007794951.1 outer membrane permeability protein SanA -
P262_RS06805 1436160..1437044 - 885 WP_007776555.1 cytidine deaminase -
P262_RS06810 1437174..1437869 - 696 WP_007776554.1 CidB/LrgB family autolysis modulator -
P262_RS06815 1437866..1438267 - 402 WP_007776553.1 CidA/LrgA family protein -
P262_RS06820 1438521..1438868 + 348 WP_007776552.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P262_RS06825 1438869..1439168 + 300 WP_007776551.1 XRE family transcriptional regulator Antitoxin
P262_RS06830 1439239..1440171 + 933 WP_007776525.1 tRNA dihydrouridine(16) synthase DusC -
P262_RS06835 1440174..1441097 - 924 WP_007776522.1 LysR family transcriptional regulator -
P262_RS06840 1441173..1442129 + 957 WP_032983658.1 MBL fold metallo-hydrolase -
P262_RS21960 1442166..1442249 - 84 WP_000691708.1 protein YohP -
P262_RS06845 1442422..1443195 + 774 WP_007794933.1 SDR family oxidoreductase -
P262_RS06850 1443192..1443758 - 567 WP_032983657.1 DedA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-83)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13339.54 Da        Isoelectric Point: 9.8707

>T30382 WP_007776552.1 NC_023032:1438521-1438868 [Cronobacter malonaticus]
MWTIYLTHEFECWLARQPQPLQEDVLAALGLLKIKGPHLGHPYADTLKGSRHAGMKELRVQHAGGPIRAFYAFDPHRYAI
VLCAAEKKGDEKRFYRVMLRVANKLFSHYLNHREV

Download         Length: 348 bp

>T30382 NC_023032:1438521-1438868 [Cronobacter malonaticus]
ATGTGGACTATTTACCTCACTCACGAGTTTGAGTGCTGGCTCGCGAGGCAGCCGCAGCCGTTGCAGGAAGATGTGCTGGC
GGCGCTGGGGCTTTTGAAAATCAAAGGCCCGCACCTCGGGCATCCGTATGCCGATACGCTCAAAGGCTCGCGTCACGCAG
GCATGAAGGAATTACGGGTTCAGCACGCCGGGGGGCCCATACGTGCCTTTTACGCTTTTGATCCGCACCGTTACGCCATT
GTGCTGTGCGCGGCAGAGAAAAAGGGCGATGAAAAGCGCTTTTACCGGGTCATGCTGCGCGTCGCTAACAAACTGTTTAG
CCATTATCTGAACCACCGGGAGGTATAG

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11035.67 Da        Isoelectric Point: 5.1667

>AT30382 WP_007776551.1 NC_023032:1438869-1439168 [Cronobacter malonaticus]
MKTFDEVLAAQTPEARARIEEKTAQLLLETHLYALREALSVSQTEMARQMGIAQPSVAAIEQRGNEMKISTLKRYVEALG
GTVRLDVELPDGQRFGFTL

Download         Length: 300 bp

>AT30382 NC_023032:1438869-1439168 [Cronobacter malonaticus]
ATGAAGACGTTTGATGAGGTGCTGGCGGCGCAGACGCCGGAGGCCCGCGCGCGTATTGAAGAGAAAACGGCGCAGCTGCT
GCTGGAAACCCACCTTTATGCGCTGCGCGAGGCGCTCAGCGTGTCGCAAACCGAGATGGCGCGCCAGATGGGTATCGCAC
AACCGTCGGTCGCGGCTATTGAACAGCGCGGCAACGAGATGAAAATCTCGACGCTGAAGCGCTATGTCGAAGCTCTGGGC
GGCACGGTGCGGCTGGATGTCGAGCTGCCGGACGGCCAGCGTTTCGGTTTTACGCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V5TX81

Antitoxin

Source ID Structure
AlphaFold DB A0A2S9UA72

References