Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ(toxin)
Location 359355..359943 Replicon chromosome
Accession NC_022911
Organism Helicobacter pylori BM012S

Toxin (Protein)


Gene name TfiT Uniprot ID M3P300
Locus tag U064_RS01910 Protein ID WP_000921941.1
Coordinates 359355..359636 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name TfiA Uniprot ID V5NLP9
Locus tag U064_RS01915 Protein ID WP_023591735.1
Coordinates 359629..359943 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
U064_RS01880 354475..355128 - 654 WP_023591539.1 IS607-like element IS607 family transposase -
U064_RS01885 355209..355922 - 714 Protein_351 competence protein -
U064_RS01890 355965..356435 - 471 Protein_352 hypothetical protein -
U064_RS01895 356528..357235 + 708 WP_023591733.1 hypothetical protein -
U064_RS01900 357240..357611 + 372 WP_038419701.1 hypothetical protein -
U064_RS08330 357708..359090 + 1383 Protein_355 type IV secretory system conjugative DNA transfer family protein -
U064_RS01910 359355..359636 - 282 WP_000921941.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
U064_RS01915 359629..359943 - 315 WP_023591735.1 hypothetical protein Antitoxin
U064_RS01920 360281..362191 + 1911 WP_038420352.1 relaxase/mobilization nuclease domain-containing protein -
U064_RS01925 362216..363400 - 1185 WP_023591737.1 hypothetical protein -
U064_RS01930 363444..363728 - 285 WP_000394639.1 hypothetical protein -
U064_RS01935 363809..364465 - 657 WP_023591738.1 ParA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10891.80 Da        Isoelectric Point: 9.5726

>T30353 WP_000921941.1 NC_022911:c359636-359355 [Helicobacter pylori BM012S]
MLKVRTKKDFLKDFNKHILSGRITESDVTSVVDCLKEQKPLQQKYCDHALSGNLKGLRECHVKPNLLLIYEIKKQENELV
LLRLDTHSELFKK

Download         Length: 282 bp

>T30353 NC_022911:c359636-359355 [Helicobacter pylori BM012S]
ATGCTTAAAGTCAGAACTAAGAAAGATTTTCTTAAAGACTTTAATAAGCATATCTTATCTGGGCGTATTACAGAAAGCGA
TGTTACAAGCGTTGTTGATTGCCTAAAAGAACAAAAACCACTCCAACAAAAATATTGCGACCACGCTTTGAGTGGCAATC
TTAAAGGGTTGAGAGAATGCCATGTCAAGCCAAACTTGTTATTGATTTATGAAATCAAAAAACAAGAAAACGAACTTGTT
TTATTGCGTCTAGACACTCATAGCGAGCTATTTAAAAAGTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12296.75 Da        Isoelectric Point: 5.6815

>AT30353 WP_023591735.1 NC_022911:c359943-359629 [Helicobacter pylori BM012S]
MSNIITDYSQYNEKQLHNFLNSIEKQLLKAEENKNKAIKKIQECELQERMIRQVLAQKHSQEKEPTQSLLNTIASKDDPE
YDVSFGDFNDFLQIAKQERERHNA

Download         Length: 315 bp

>AT30353 NC_022911:c359943-359629 [Helicobacter pylori BM012S]
ATGTCAAATATTATTACAGATTACTCGCAATACAATGAAAAGCAACTGCACAATTTCTTAAACTCCATTGAAAAACAATT
GCTTAAGGCAGAAGAGAATAAAAATAAAGCGATAAAAAAAATCCAAGAGTGTGAATTGCAAGAACGAATGATCAGACAAG
TTTTAGCCCAAAAACATTCTCAAGAAAAGGAACCCACACAAAGTTTGTTAAATACGATCGCCTCAAAAGATGACCCAGAA
TACGATGTTTCGTTTGGAGACTTCAATGATTTTTTACAAATAGCAAAACAAGAAAGAGAAAGGCATAATGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M3P300

Antitoxin

Source ID Structure
AlphaFold DB V5NLP9

References