Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) hok-sok/-
Location 43331..43595 Replicon plasmid pHUSEC2011-1
Accession NC_022742
Organism Escherichia coli

Toxin (Protein)


Gene name pndA Uniprot ID U9Z417
Locus tag HUS2011_RS27715 Protein ID WP_001387489.1
Coordinates 43443..43595 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name pndB
Locus tag -
Coordinates 43331..43393 (-)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUS2011_RS27700 39433..40503 - 1071 WP_000151588.1 IncI1-type conjugal transfer protein TrbB -
HUS2011_RS27705 40522..41730 - 1209 WP_000121263.1 IncI1-type conjugal transfer protein TrbA -
HUS2011_RS27710 42037..43128 - 1092 WP_000426061.1 hypothetical protein -
- 43331..43393 - 63 NuclAT_0 - Antitoxin
- 43331..43393 - 63 NuclAT_0 - Antitoxin
- 43331..43393 - 63 NuclAT_0 - Antitoxin
- 43331..43393 - 63 NuclAT_0 - Antitoxin
HUS2011_RS27715 43443..43595 + 153 WP_001387489.1 Hok/Gef family protein Toxin
HUS2011_RS27720 43667..43918 - 252 WP_001291964.1 hypothetical protein -
HUS2011_RS27725 44218..44514 + 297 WP_001275298.1 hypothetical protein -
HUS2011_RS31775 44579..44755 - 177 WP_001054898.1 hypothetical protein -
HUS2011_RS27740 44938..45147 - 210 WP_001140543.1 hemolysin expression modulator Hha -
HUS2011_RS27745 45245..45859 - 615 WP_000578648.1 plasmid IncI1-type surface exclusion protein ExcA -
HUS2011_RS27750 45935..48103 - 2169 WP_000698360.1 IncI1-type conjugal transfer membrane protein TraY -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaCTX-M-15 / blaTEM-1B - 1..88546 88546


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(7-46)


Sequences


Toxin        


Download         Length: 51 a.a.        Molecular weight: 5761.10 Da        Isoelectric Point: 8.7948

>T30309 WP_001387489.1 NC_022742:43443-43595 [Escherichia coli]
MPQRTFLMMLIVVCVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR

Download         Length: 153 bp

>T30309 NC_022742:43443-43595 [Escherichia coli]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCGTCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 63 bp

>AT30309 NC_022742:c43393-43331 [Escherichia coli]
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB U9Z417


Antitoxin

Download structure file

References