Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1432844..1433363 Replicon chromosome
Accession NC_022737
Organism Staphylococcus pasteuri SP1

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2V3ZBG9
Locus tag STP1_RS06925 Protein ID WP_023374423.1
Coordinates 1432844..1433116 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2V3ZEN9
Locus tag STP1_RS06930 Protein ID WP_023374424.1
Coordinates 1433109..1433363 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
STP1_RS06910 1429408..1430274 + 867 WP_023374420.1 SDR family NAD(P)-dependent oxidoreductase -
STP1_RS06915 1430501..1431139 + 639 WP_023374421.1 NAD(P)H-dependent oxidoreductase -
STP1_RS06920 1431232..1432602 - 1371 WP_023374422.1 citrate:proton symporter -
STP1_RS06925 1432844..1433116 - 273 WP_023374423.1 Txe/YoeB family addiction module toxin Toxin
STP1_RS06930 1433109..1433363 - 255 WP_023374424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
STP1_RS06935 1433609..1435810 + 2202 WP_023374425.1 YSIRK-type signal peptide-containing protein -
STP1_RS06940 1435937..1436374 - 438 WP_023374426.1 hypothetical protein -
STP1_RS06945 1436520..1437842 - 1323 WP_023374427.1 PrsW family intramembrane metalloprotease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10878.67 Da        Isoelectric Point: 10.1042

>T30305 WP_023374423.1 NC_022737:c1433116-1432844 [Staphylococcus pasteuri SP1]
MSRLNILFTPDAFEDYKYWQIHDKKLLKKINHFIKCINRNGPLQGEGKPEALKGNFKGYYSRRINFEHRLVYKVYDSSII
IVSCKYHYFK

Download         Length: 273 bp

>T30305 NC_022737:c1433116-1432844 [Staphylococcus pasteuri SP1]
ATGAGTAGATTAAATATTTTATTTACACCTGATGCATTTGAAGATTATAAATATTGGCAAATTCATGATAAAAAATTATT
AAAAAAGATTAACCATTTTATTAAATGTATAAATCGTAATGGCCCACTCCAAGGCGAAGGAAAACCTGAAGCTTTGAAAG
GGAATTTTAAAGGATATTATAGTAGAAGAATCAATTTTGAACATAGGTTAGTTTATAAAGTATACGATTCATCCATCATT
ATTGTTTCTTGTAAATATCATTATTTTAAATAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9371.35 Da        Isoelectric Point: 4.0334

>AT30305 WP_023374424.1 NC_022737:c1433363-1433109 [Staphylococcus pasteuri SP1]
MAIVSYSIARKNFRSLIDKVNNDSDAVTITTNDSNAVLISESDYNAMMETLYLQQSPANAQHLAKSIEDAERGNTIEVDL
ELYE

Download         Length: 255 bp

>AT30305 NC_022737:c1433363-1433109 [Staphylococcus pasteuri SP1]
ATGGCAATAGTATCGTACTCAATAGCTAGAAAAAATTTTAGAAGTTTAATAGATAAAGTAAACAATGATTCAGATGCAGT
GACTATAACAACTAATGATAGTAATGCTGTATTGATTTCTGAGTCAGATTACAATGCGATGATGGAGACATTATACCTCC
AACAATCCCCTGCTAATGCCCAACACTTGGCTAAATCTATAGAAGATGCTGAGCGTGGAAATACAATAGAGGTAGATTTA
GAATTATATGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2V3ZBG9

Antitoxin

Source ID Structure
AlphaFold DB A0A2V3ZEN9

References