30297

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 2071706..2072225 Replicon chromosome
Accession NC_022665
Organism Streptococcus suis T15

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0K2E7Z7
Locus tag T15_RS10355 Protein ID WP_013730620.1
Coordinates 2071706..2071963 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0K2E7Z9
Locus tag T15_RS10360 Protein ID WP_002939010.1
Coordinates 2071965..2072225 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
T15_RS10340 2068179..2069909 - 1731 WP_023371683.1 membrane protein -
T15_RS10345 2070272..2071144 - 873 WP_014736465.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
T15_RS10350 2071163..2071642 - 480 WP_074389919.1 DUF1697 domain-containing protein -
T15_RS10355 2071706..2071963 - 258 WP_013730620.1 Txe/YoeB family addiction module toxin Toxin
T15_RS10360 2071965..2072225 - 261 WP_002939010.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
T15_RS10365 2072301..2072756 - 456 WP_012028534.1 8-oxo-dGTP diphosphatase -
T15_RS10370 2072763..2073092 - 330 WP_012775364.1 type II toxin-antitoxin system RelE/ParE family toxin -
T15_RS10375 2073082..2073369 - 288 WP_023371687.1 hypothetical protein -
T15_RS10380 2073467..2073835 - 369 WP_023371689.1 hypothetical protein -
T15_RS10385 2073828..2074397 - 570 WP_012775700.1 ribonuclease M5 -
T15_RS10390 2074381..2075163 - 783 WP_012028536.1 TatD family hydrolase -
T15_RS10395 2075270..2075407 - 138 WP_002939016.1 50S ribosomal protein L34 -
T15_RS10400 2075650..2076737 + 1088 Protein_2000 IS30 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2058500..2075163 16663
- flank IS/Tn - - 2076195..2076737 542


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10346.86 Da        Isoelectric Point: 8.0279

>T30297 WP_013730620.1 NC_022665:c2071963-2071706 [Streptococcus suis T15]
MGIHFTDDAWEDYLYWQGQDKKTLKRINKIIKDMQRHPFEGIAKPEPLKYDYQGAWSRRIDAENRLIYMVEADRLCILSL
KDHYR

Download         Length: 258 bp

>T30297 NC_022665:c2071963-2071706 [Streptococcus suis T15]
ATGGGAATCCATTTTACAGACGACGCCTGGGAAGACTATCTTTATTGGCAAGGTCAGGATAAGAAAACACTGAAGAGAAT
CAATAAGATTATCAAGGATATGCAGCGACATCCTTTTGAAGGCATTGCCAAACCAGAACCTTTGAAGTATGATTATCAAG
GTGCCTGGTCAAGAAGGATTGATGCGGAGAATCGGTTGATTTATATGGTGGAAGCTGATCGGTTGTGCATCCTGTCGCTA
AAGGATCATTATAGGTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9980.36 Da        Isoelectric Point: 5.7134

>AT30297 WP_002939010.1 NC_022665:c2072225-2071965 [Streptococcus suis T15]
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLAVARNTYLSQKVLRGMAKVKTGQTQER
NLIEAD

Download         Length: 261 bp

>AT30297 NC_022665:c2072225-2071965 [Streptococcus suis T15]
ATGGAAGCTATTGTATATTCCCATTTTCGAAATCACTTAAAGGACTATATGAAAAAGGTCAATGACGAGTTTGAACCTTT
GGTCGTGGTTAATAAAAATCCAGAGGAAGATATTGTTGTACTCTCAAAGAGTGAGTGGGATAGTTTACAAGAAACCCTCG
CTGTTGCTCGGAACACTTATCTGTCTCAAAAAGTCCTACGTGGTATGGCTAAAGTCAAAACGGGACAAACCCAAGAACGA
AACCTGATAGAGGCGGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K2E7Z7

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2E7Z9

References