Detailed information of TA system TA030291

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 4770767..4771446
• Replicon: chromosome
• Accession: NC_022663
• Organism: Mycobacterium kansasii ATCC 12478

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: MKAN_RS20835
• Protein ID: WP_023371785.1
• Coordinates: 4771093..4771446 (-)
• Length: 118 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: MKAN_RS20830
• Protein ID: WP_023371783.1
• Coordinates: 4770767..4771096 (-)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MKAN_RS20805	4766750..4767955	-	1206	WP_023371775.1	RtcB family protein	-
MKAN_RS29915	4768968..4770608	+	1641	WP_080674111.1	AAA family ATPase	-
MKAN_RS20830	4770767..4771096	-	330	WP_023371783.1	XRE family transcriptional regulator	Antitoxin
MKAN_RS20835	4771093..4771446	-	354	WP_023371785.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MKAN_RS20840	4771493..4771669	-	177	Protein_4173	site-specific integrase	-
MKAN_RS28905	4771735..4773834	-	2100	WP_023371789.1	hypothetical protein	-
MKAN_RS20850	4773841..4774125	-	285	WP_042313875.1	helix-turn-helix transcriptional regulator	-
MKAN_RS20855	4774164..4775168	-	1005	WP_172836709.1	tyrosine-type recombinase/integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	4687651..4781359	93708

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (16-108)

Antitoxin

• HigA2-like, helix-turn-helix domain (35-97)

Sequences

Toxin

Protein

• Length: 118 a.a.
• Molecular weight: 13268.09 Da
• Isoelectric Point: 4.4057

>T30291 WP_023371785.1 NC_022663:c4771446-4771093 [Mycobacterium kansasii ATCC 12478]
MSMSWDVILLEEVEAWYFSLDDEAMAAVTGAIDLLELEGPTLGRPTVDKVKGSKFHSLKELRPAGTSIRILFIFDPRRQA
ILLLGGDKAGNWKRWYEENIPVADQRYENWLANEGGE

Nucleotide

• Length: 354 bp

>T30291 NC_022663:c4771446-4771093 [Mycobacterium kansasii ATCC 12478]
ATGTCGATGTCCTGGGATGTGATCCTGCTCGAGGAGGTCGAAGCCTGGTACTTCTCGCTCGACGACGAAGCGATGGCAGC
AGTCACCGGGGCCATCGACCTGCTCGAGCTGGAAGGACCAACGCTAGGCCGGCCGACGGTGGACAAGGTAAAGGGATCGA
AGTTCCACAGCTTGAAGGAGCTGCGGCCGGCGGGTACCAGCATTCGGATCCTGTTCATCTTCGATCCACGACGGCAGGCG
ATCCTGCTGCTTGGCGGGGACAAGGCAGGCAACTGGAAGCGCTGGTACGAGGAGAACATTCCGGTGGCCGATCAGCGATA
TGAGAACTGGCTGGCGAACGAGGGAGGTGAATGA

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 11701.20 Da
• Isoelectric Point: 7.4048

>AT30291 WP_023371783.1 NC_022663:c4771096-4770767 [Mycobacterium kansasii ATCC 12478]
MIVARNWREIRAEAVAQGRLDPARADAARKEMHDAVQAQRLADIRKAHGHARQADVAALMGVSQARVSKLESGDLSHTEL
GTLQSYVAALGGNLRIVADFGESSVELTA

Nucleotide

• Length: 330 bp

>AT30291 NC_022663:c4771096-4770767 [Mycobacterium kansasii ATCC 12478]
ATGATCGTGGCACGCAACTGGCGTGAGATTCGTGCGGAGGCGGTTGCGCAGGGGCGGCTGGACCCGGCGCGCGCCGACGC
AGCACGCAAAGAAATGCACGACGCCGTCCAGGCCCAGCGCCTTGCTGACATTCGCAAGGCGCATGGACATGCCCGGCAGG
CCGACGTCGCCGCTTTGATGGGGGTGTCGCAGGCACGCGTGTCAAAGCTCGAAAGCGGCGACCTGTCGCACACGGAGCTG
GGCACGCTGCAGTCGTACGTCGCCGCCCTCGGCGGGAATCTTCGAATCGTTGCCGACTTCGGCGAGAGCAGCGTGGAACT
GACAGCATGA