Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2290010..2290512 Replicon chromosome
Accession NC_022648
Organism Escherichia coli JJ1886

Toxin (Protein)


Gene name yoeB Uniprot ID E2QNP2
Locus tag P423_RS11930 Protein ID WP_000767819.1
Coordinates 2290010..2290264 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID E2QNP3
Locus tag P423_RS11935 Protein ID WP_001259253.1
Coordinates 2290261..2290512 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P423_RS11905 2285828..2286286 - 459 WP_023363206.1 IS200/IS605 family transposase -
P423_RS11915 2286503..2287861 - 1359 WP_000019194.1 putrescine/proton symporter PlaP -
P423_RS29990 2287851..2287913 - 63 WP_010723108.1 membrane protein YoeI -
P423_RS11920 2288128..2289057 - 930 WP_000803366.1 LysR family transcriptional regulator -
P423_RS11925 2289103..2289927 - 825 WP_000754737.1 SDR family oxidoreductase -
P423_RS11930 2290010..2290264 - 255 WP_000767819.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
P423_RS11935 2290261..2290512 - 252 WP_001259253.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
P423_RS27870 2290795..2290845 + 51 WP_001364200.1 his operon leader peptide -
P423_RS11940 2290991..2291890 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
P423_RS11945 2291896..2293200 + 1305 WP_001296211.1 histidinol dehydrogenase -
P423_RS11950 2293197..2294267 + 1071 WP_000108967.1 histidinol-phosphate transaminase -
P423_RS11955 2294267..2295334 + 1068 WP_000080057.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2285828..2286286 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10110.53 Da        Isoelectric Point: 7.2749

>T30250 WP_000767819.1 NC_022648:c2290264-2290010 [Escherichia coli JJ1886]
VKLIWSEESWDDYLYWQEADKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHLLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T30250 NC_022648:c2290264-2290010 [Escherichia coli JJ1886]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAGCAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAACTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCTTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9365.62 Da        Isoelectric Point: 4.6127

>AT30250 WP_001259253.1 NC_022648:c2290512-2290261 [Escherichia coli JJ1886]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSDKGTEKD
IIE

Download         Length: 252 bp

>AT30250 NC_022648:c2290512-2290261 [Escherichia coli JJ1886]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGACAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E2QNP2

Antitoxin

Source ID Structure
AlphaFold DB E2QNP3

References