Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 2361231..2361494 Replicon chromosome
Accession NC_022604
Organism Staphylococcus aureus subsp. aureus Z172

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag SAZ172_RS12255 Protein ID WP_001802298.1
Coordinates 2361390..2361494 (-) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF4
Locus tag -
Coordinates 2361231..2361395 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAZ172_RS12235 2357414..2358079 - 666 WP_001024094.1 SDR family oxidoreductase -
SAZ172_RS12240 2358231..2358551 + 321 WP_000003759.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
SAZ172_RS12245 2358553..2359533 + 981 WP_000019744.1 CDF family zinc efflux transporter CzrB -
SAZ172_RS12250 2359799..2360890 + 1092 WP_000495671.1 lytic regulatory protein -
- 2361231..2361395 + 165 - - Antitoxin
SAZ172_RS12255 2361390..2361494 - 105 WP_001802298.1 hypothetical protein Toxin
SAZ172_RS16610 2361655..2362138 - 484 Protein_2334 recombinase family protein -
SAZ172_RS12265 2362181..2363317 - 1137 WP_000115564.1 SAP domain-containing protein -
SAZ172_RS12270 2363606..2363698 + 93 WP_001790138.1 hypothetical protein -
SAZ172_RS12275 2364404..2365261 - 858 WP_000370924.1 Cof-type HAD-IIB family hydrolase -
SAZ172_RS12280 2365329..2366111 - 783 WP_000908176.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-112)


Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T30226 WP_001802298.1 NC_022604:c2361494-2361390 [Staphylococcus aureus subsp. aureus Z172]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T30226 NC_022604:c2361494-2361390 [Staphylococcus aureus subsp. aureus Z172]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTTATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 165 bp

>AT30226 NC_022604:2361231-2361395 [Staphylococcus aureus subsp. aureus Z172]
GTAGTAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References