Detailed information of TA system TA030217

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2112718..2113017
• Replicon: chromosome
• Accession: NC_022604
• Organism: Staphylococcus aureus subsp. aureus Z172

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A4U0AGH1
• Locus tag: SAZ172_RS16195
• Protein ID: WP_072482930.1
• Coordinates: 2112841..2113017 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2112718..2112773 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAZ172_RS10645	2108277..2108456	+	180	WP_000669789.1	hypothetical protein	-
SAZ172_RS10655	2108767..2109027	+	261	WP_001791826.1	hypothetical protein	-
SAZ172_RS10660	2109080..2109430	-	351	WP_000702262.1	complement inhibitor SCIN-A	-
SAZ172_RS16580	2109939..2110274	-	336	Protein_2024	SH3 domain-containing protein	-
SAZ172_RS10670	2110926..2111417	-	492	WP_000920041.1	staphylokinase	-
SAZ172_RS10675	2111608..2112363	-	756	WP_000861038.1	CHAP domain-containing protein	-
SAZ172_RS10680	2112375..2112629	-	255	WP_000611512.1	phage holin	-
SAZ172_RS10685	2112681..2112788	+	108	Protein_2028	hypothetical protein	-
-	2112710..2112849	+	140	NuclAT_0	-	-
-	2112710..2112849	+	140	NuclAT_0	-	-
-	2112710..2112849	+	140	NuclAT_0	-	-
-	2112710..2112849	+	140	NuclAT_0	-	-
-	2112718..2112773	+	56	-	-	Antitoxin
SAZ172_RS16195	2112841..2113017	-	177	WP_072482930.1	putative holin-like toxin	Toxin
SAZ172_RS10695	2113126..2113899	-	774	WP_000750412.1	staphylococcal enterotoxin type A	-
SAZ172_RS10700	2114272..2114646	-	375	WP_000340977.1	hypothetical protein	-
SAZ172_RS10705	2114702..2114989	-	288	WP_001262621.1	hypothetical protein	-
SAZ172_RS10710	2115035..2115187	-	153	WP_001000059.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / sea / hlb / groEL	2109080..2166604	57524

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6883.46 Da
• Isoelectric Point: 10.6777

>T30217 WP_072482930.1 NC_022604:c2113017-2112841 [Staphylococcus aureus subsp. aureus Z172]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIAFIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T30217 NC_022604:c2113017-2112841 [Staphylococcus aureus subsp. aureus Z172]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTCATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT30217 NC_022604:2112718-2112773 [Staphylococcus aureus subsp. aureus Z172]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A4U0AGH1

Antitoxin