Detailed information of TA system TA030214

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1954026..1954205
• Replicon: chromosome
• Accession: NC_022604
• Organism: Staphylococcus aureus subsp. aureus Z172

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: SAZ172_RS16565
• Protein ID: WP_144316852.1
• Coordinates: 1954026..1954121 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1954147..1954205 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAZ172_RS09660	1949685..1950311	+	627	WP_000669046.1	hypothetical protein	-
SAZ172_RS09665	1950352..1950696	+	345	WP_000627551.1	DUF3969 family protein	-
SAZ172_RS09670	1950794..1951345	+	552	WP_000414205.1	hypothetical protein	-
SAZ172_RS09675	1951563..1952204	-	642	WP_000494956.1	ImmA/IrrE family metallo-endopeptidase	-
SAZ172_RS09680	1952318..1952503	-	186	WP_000809857.1	hypothetical protein	-
SAZ172_RS09685	1952505..1952681	-	177	WP_000375476.1	hypothetical protein	-
SAZ172_RS09690	1952692..1953075	-	384	WP_000070811.1	hypothetical protein	-
SAZ172_RS09700	1953679..1953822	-	144	WP_001549059.1	transposase	-
SAZ172_RS16565	1954026..1954121	+	96	WP_144316852.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	1954147..1954205	-	59	-	-	Antitoxin
SAZ172_RS09705	1954241..1954342	+	102	WP_001791893.1	hypothetical protein	-
SAZ172_RS16115	1954320..1954496	-	177	Protein_1874	transposase	-
SAZ172_RS09710	1954690..1955067	-	378	WP_001037045.1	DUF1433 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukD / hlgA	1928000..1985629	57629

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-124)

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3572.24 Da
• Isoelectric Point: 9.2774

>T30214 WP_144316852.1 NC_022604:1954026-1954121 [Staphylococcus aureus subsp. aureus Z172]
MLEILVHITTTVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T30214 NC_022604:1954026-1954121 [Staphylococcus aureus subsp. aureus Z172]
ATGCTAGAAATTCTTGTTCACATCACGACCACAGTCATCAGTGGTTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin

Nucleotide

• Length: 59 bp

>AT30214 NC_022604:c1954205-1954147 [Staphylococcus aureus subsp. aureus Z172]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTGCCGTAGTGAGGGG

Structures

Antitoxin