Detailed information of TA system TA030192

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 2674800..2675424
• Replicon: chromosome
• Accession: NC_022567
• Organism: Adlercreutzia equolifaciens DSM 19450

Toxin (Protein)

• Gene name: graT
• Uniprot ID: -
• Locus tag: AEQU_RS10845
• Protein ID: WP_022741509.1
• Coordinates: 2674800..2675081 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: AEQU_RS10850
• Protein ID: WP_197536819.1
• Coordinates: 2675104..2675424 (+)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AEQU_RS10820	2670072..2670815	-	744	WP_022741488.1	response regulator transcription factor	-
AEQU_RS10825	2670802..2672322	-	1521	WP_022741492.1	DUF3365 domain-containing protein	-
AEQU_RS10830	2672474..2673028	-	555	WP_022741495.1	flavin reductase	-
AEQU_RS10835	2673166..2673567	-	402	WP_022741498.1	pyridoxamine 5'-phosphate oxidase family protein	-
AEQU_RS12385	2673695..2674234	+	540	WP_022741502.1	helix-turn-helix transcriptional regulator	-
AEQU_RS10845	2674800..2675081	+	282	WP_022741509.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AEQU_RS10850	2675104..2675424	+	321	WP_197536819.1	HigA family addiction module antidote protein	Antitoxin
AEQU_RS10855	2675595..2676452	-	858	WP_022741516.1	pyridoxamine kinase	-
AEQU_RS10860	2676567..2677628	-	1062	WP_022741518.1	nucleoid-associated protein	-
AEQU_RS10865	2677638..2678507	-	870	WP_084280735.1	hypothetical protein	-
AEQU_RS10870	2678534..2680138	-	1605	WP_022741520.1	DUF853 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (3-93)

Antitoxin

• Cro/C1-type helix-turn-helix domain (26-73)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10754.27 Da
• Isoelectric Point: 7.1336

>T30192 WP_022741509.1 NC_022567:2674800-2675081 [Adlercreutzia equolifaciens DSM 19450]
MIKTFADSDTRALFETGQSKRLPADIVRRALRKLEYVDNAVLLTDLRLPPGNRLHALKGDRAGQFSISINDQWRICFRFE
PEGVYDVEICDYH

Nucleotide

• Length: 282 bp

>T30192 NC_022567:2674800-2675081 [Adlercreutzia equolifaciens DSM 19450]
ATGATAAAGACGTTCGCCGATTCCGACACACGGGCGCTGTTCGAAACGGGACAGAGCAAAAGACTTCCTGCCGACATCGT
TCGCCGGGCGCTGCGAAAGCTGGAGTACGTCGACAACGCGGTCTTGCTGACCGATCTTCGACTTCCGCCGGGCAACCGGC
TGCACGCCCTGAAGGGCGATCGCGCCGGCCAGTTCTCGATTTCCATCAACGACCAATGGCGCATTTGCTTCAGGTTCGAA
CCCGAAGGAGTCTACGATGTCGAGATATGCGACTACCATTGA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 12073.02 Da
• Isoelectric Point: 4.5467

>AT30192 WP_197536819.1 NC_022567:2675104-2675424 [Adlercreutzia equolifaciens DSM 19450]
MNDDMIMVSREPVHPGEFLREDYMPELGLTVATLAKRLGVSRQTVNDIVREKRGLSPEMCLRLGRLFGTTPQFWMNMQSK
VDIWDSLALHEDEVMAIEPIEIAAIA

Nucleotide

• Length: 321 bp

>AT30192 NC_022567:2675104-2675424 [Adlercreutzia equolifaciens DSM 19450]
ATGAACGATGACATGATTATGGTGTCGCGCGAGCCCGTGCACCCGGGCGAGTTTTTGCGCGAGGATTATATGCCGGAGCT
GGGACTGACGGTGGCGACGCTGGCGAAGCGGCTGGGCGTATCGCGGCAGACCGTCAACGACATCGTGCGCGAGAAGCGGG
GCCTGAGCCCGGAGATGTGCCTTCGCCTGGGACGCCTGTTCGGCACAACGCCCCAGTTCTGGATGAACATGCAGTCGAAG
GTGGACATCTGGGACTCTCTGGCGCTGCACGAGGACGAGGTCATGGCCATCGAGCCCATCGAGATAGCCGCCATCGCATA
A