Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2674800..2675424 Replicon chromosome
Accession NC_022567
Organism Adlercreutzia equolifaciens DSM 19450

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag AEQU_RS10845 Protein ID WP_022741509.1
Coordinates 2674800..2675081 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag AEQU_RS10850 Protein ID WP_197536819.1
Coordinates 2675104..2675424 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AEQU_RS10820 2670072..2670815 - 744 WP_022741488.1 response regulator transcription factor -
AEQU_RS10825 2670802..2672322 - 1521 WP_022741492.1 DUF3365 domain-containing protein -
AEQU_RS10830 2672474..2673028 - 555 WP_022741495.1 flavin reductase -
AEQU_RS10835 2673166..2673567 - 402 WP_022741498.1 pyridoxamine 5'-phosphate oxidase family protein -
AEQU_RS12385 2673695..2674234 + 540 WP_022741502.1 helix-turn-helix transcriptional regulator -
AEQU_RS10845 2674800..2675081 + 282 WP_022741509.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AEQU_RS10850 2675104..2675424 + 321 WP_197536819.1 HigA family addiction module antidote protein Antitoxin
AEQU_RS10855 2675595..2676452 - 858 WP_022741516.1 pyridoxamine kinase -
AEQU_RS10860 2676567..2677628 - 1062 WP_022741518.1 nucleoid-associated protein -
AEQU_RS10865 2677638..2678507 - 870 WP_084280735.1 hypothetical protein -
AEQU_RS10870 2678534..2680138 - 1605 WP_022741520.1 DUF853 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(26-73)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10754.27 Da        Isoelectric Point: 7.1336

>T30192 WP_022741509.1 NC_022567:2674800-2675081 [Adlercreutzia equolifaciens DSM 19450]
MIKTFADSDTRALFETGQSKRLPADIVRRALRKLEYVDNAVLLTDLRLPPGNRLHALKGDRAGQFSISINDQWRICFRFE
PEGVYDVEICDYH

Download         Length: 282 bp

>T30192 NC_022567:2674800-2675081 [Adlercreutzia equolifaciens DSM 19450]
ATGATAAAGACGTTCGCCGATTCCGACACACGGGCGCTGTTCGAAACGGGACAGAGCAAAAGACTTCCTGCCGACATCGT
TCGCCGGGCGCTGCGAAAGCTGGAGTACGTCGACAACGCGGTCTTGCTGACCGATCTTCGACTTCCGCCGGGCAACCGGC
TGCACGCCCTGAAGGGCGATCGCGCCGGCCAGTTCTCGATTTCCATCAACGACCAATGGCGCATTTGCTTCAGGTTCGAA
CCCGAAGGAGTCTACGATGTCGAGATATGCGACTACCATTGA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12073.02 Da        Isoelectric Point: 4.5467

>AT30192 WP_197536819.1 NC_022567:2675104-2675424 [Adlercreutzia equolifaciens DSM 19450]
MNDDMIMVSREPVHPGEFLREDYMPELGLTVATLAKRLGVSRQTVNDIVREKRGLSPEMCLRLGRLFGTTPQFWMNMQSK
VDIWDSLALHEDEVMAIEPIEIAAIA

Download         Length: 321 bp

>AT30192 NC_022567:2675104-2675424 [Adlercreutzia equolifaciens DSM 19450]
ATGAACGATGACATGATTATGGTGTCGCGCGAGCCCGTGCACCCGGGCGAGTTTTTGCGCGAGGATTATATGCCGGAGCT
GGGACTGACGGTGGCGACGCTGGCGAAGCGGCTGGGCGTATCGCGGCAGACCGTCAACGACATCGTGCGCGAGAAGCGGG
GCCTGAGCCCGGAGATGTGCCTTCGCCTGGGACGCCTGTTCGGCACAACGCCCCAGTTCTGGATGAACATGCAGTCGAAG
GTGGACATCTGGGACTCTCTGGCGCTGCACGAGGACGAGGTCATGGCCATCGAGCCCATCGAGATAGCCGCCATCGCATA
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References