Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1875452..1875971 Replicon chromosome
Accession NC_022516
Organism Streptococcus suis YB51

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0K2E7Z7
Locus tag YB51_RS09225 Protein ID WP_013730620.1
Coordinates 1875452..1875709 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0K2E7Z9
Locus tag YB51_RS09230 Protein ID WP_002939010.1
Coordinates 1875711..1875971 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
YB51_RS09210 1871923..1873653 - 1731 WP_013730619.1 membrane protein -
YB51_RS09215 1874016..1874924 - 909 WP_074411269.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
YB51_RS09220 1874908..1875438 - 531 WP_009910909.1 DUF1697 domain-containing protein -
YB51_RS09225 1875452..1875709 - 258 WP_013730620.1 Txe/YoeB family addiction module toxin Toxin
YB51_RS09230 1875711..1875971 - 261 WP_002939010.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
YB51_RS09235 1876047..1876502 - 456 WP_013730621.1 8-oxo-dGTP diphosphatase -
YB51_RS09240 1876506..1876874 - 369 WP_013730622.1 hypothetical protein -
YB51_RS09245 1876867..1877436 - 570 WP_022540720.1 ribonuclease M5 -
YB51_RS09250 1877420..1878202 - 783 WP_002939015.1 TatD family hydrolase -
YB51_RS09255 1878310..1878447 - 138 WP_002939016.1 50S ribosomal protein L34 -
YB51_RS09260 1878615..1879610 - 996 WP_013730624.1 protein jag -
YB51_RS09265 1879630..1880442 - 813 WP_004194552.1 YidC/Oxa1 family membrane protein insertase -
YB51_RS09270 1880426..1880785 - 360 WP_013730625.1 ribonuclease P protein component -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10346.86 Da        Isoelectric Point: 8.0279

>T30139 WP_013730620.1 NC_022516:c1875709-1875452 [Streptococcus suis YB51]
MGIHFTDDAWEDYLYWQGQDKKTLKRINKIIKDMQRHPFEGIAKPEPLKYDYQGAWSRRIDAENRLIYMVEADRLCILSL
KDHYR

Download         Length: 258 bp

>T30139 NC_022516:c1875709-1875452 [Streptococcus suis YB51]
ATGGGAATCCATTTTACAGACGACGCCTGGGAAGACTATCTTTATTGGCAGGGTCAGGATAAGAAAACACTGAAGAGAAT
CAATAAGATTATCAAGGATATGCAGCGACATCCTTTTGAAGGCATTGCCAAACCAGAACCTTTGAAGTATGATTATCAAG
GTGCCTGGTCTCGGAGAATTGATGCGGAGAATCGGTTGATTTATATGGTGGAAGCTGATCGGTTGTGCATCCTGTCGCTA
AAGGATCATTATAGGTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9980.36 Da        Isoelectric Point: 5.7134

>AT30139 WP_002939010.1 NC_022516:c1875971-1875711 [Streptococcus suis YB51]
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLAVARNTYLSQKVLRGMAKVKTGQTQER
NLIEAD

Download         Length: 261 bp

>AT30139 NC_022516:c1875971-1875711 [Streptococcus suis YB51]
ATGGAAGCTATTGTATATTCCCATTTTCGAAATCACTTAAAGGACTATATGAAAAAGGTCAATGACGAGTTTGAACCTTT
GGTCGTGGTTAATAAAAATCCAGAGGAAGATATTGTTGTACTCTCAAAGAGTGAGTGGGATAGTTTACAAGAAACCCTCG
CTGTTGCTCGGAACACTTATCTGTCTCAAAAAGTCCTACGTGGTATGGCTAAAGTCAAAACGGGACAAACCCAAGAACGA
AACCTGATAGAGGCGGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K2E7Z7

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2E7Z9

References