Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2369878..2370395 Replicon chromosome
Accession NC_022443
Organism Staphylococcus aureus subsp. aureus SA40

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2S6D1N9
Locus tag SA40_RS11815 Protein ID WP_000113263.1
Coordinates 2369878..2370144 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag SA40_RS11820 Protein ID WP_000584499.1
Coordinates 2370144..2370395 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SA40_RS11790 2365138..2365674 - 537 WP_000185901.1 GNAT family N-acetyltransferase -
SA40_RS11795 2366087..2366911 - 825 WP_000594633.1 formate/nitrite transporter family protein -
SA40_RS11800 2367115..2367297 - 183 WP_000079140.1 hypothetical protein -
SA40_RS11805 2367384..2367851 - 468 WP_000153338.1 SRPBCC domain-containing protein -
SA40_RS11810 2368037..2369584 - 1548 WP_000727757.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
SA40_RS11815 2369878..2370144 - 267 WP_000113263.1 Txe/YoeB family addiction module toxin Toxin
SA40_RS11820 2370144..2370395 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SA40_RS11825 2370568..2370659 - 92 Protein_2226 hypothetical protein -
SA40_RS11830 2370666..2371265 - 600 WP_000162810.1 DsbA family protein -
SA40_RS11835 2371284..2371646 - 363 WP_000819839.1 DUF4467 domain-containing protein -
SA40_RS11840 2371901..2373151 + 1251 WP_001012236.1 FemA/FemB family glycyltransferase FmhA -
SA40_RS11845 2373248..2373979 - 732 WP_000615464.1 amino acid ABC transporter ATP-binding protein -
SA40_RS11850 2373976..2374695 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.01 Da        Isoelectric Point: 10.1628

>T30133 WP_000113263.1 NC_022443:c2370144-2369878 [Staphylococcus aureus subsp. aureus SA40]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T30133 NC_022443:c2370144-2369878 [Staphylococcus aureus subsp. aureus SA40]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGAAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGTTATTATAGTAGACGTATCAATCACGAACATAGATTGGTCTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT30133 WP_000584499.1 NC_022443:c2370395-2370144 [Staphylococcus aureus subsp. aureus SA40]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT30133 NC_022443:c2370395-2370144 [Staphylococcus aureus subsp. aureus SA40]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACCTCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAATCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGAAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S6D1N9

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References