30123

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2431054..2431571 Replicon chromosome
Accession NC_022442
Organism Staphylococcus aureus subsp. aureus SA957

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2S6D1N9
Locus tag SA957_RS12245 Protein ID WP_000113263.1
Coordinates 2431054..2431320 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag SA957_RS12250 Protein ID WP_000584499.1
Coordinates 2431320..2431571 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SA957_RS12220 2426314..2426850 - 537 WP_000185901.1 GNAT family N-acetyltransferase -
SA957_RS12225 2427263..2428087 - 825 WP_000594633.1 formate/nitrite transporter family protein -
SA957_RS12230 2428291..2428473 - 183 WP_000079140.1 hypothetical protein -
SA957_RS12235 2428560..2429027 - 468 WP_000153338.1 SRPBCC domain-containing protein -
SA957_RS12240 2429213..2430760 - 1548 WP_000727757.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
SA957_RS12245 2431054..2431320 - 267 WP_000113263.1 Txe/YoeB family addiction module toxin Toxin
SA957_RS12250 2431320..2431571 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SA957_RS12255 2431744..2431835 - 92 Protein_2320 hypothetical protein -
SA957_RS12260 2431842..2432441 - 600 WP_000162810.1 DsbA family protein -
SA957_RS12265 2432460..2432822 - 363 WP_000819839.1 DUF4467 domain-containing protein -
SA957_RS12270 2433077..2434327 + 1251 WP_001012236.1 FemA/FemB family glycyltransferase FmhA -
SA957_RS12275 2434424..2435155 - 732 WP_000615464.1 amino acid ABC transporter ATP-binding protein -
SA957_RS12280 2435152..2435871 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.01 Da        Isoelectric Point: 10.1628

>T30123 WP_000113263.1 NC_022442:c2431320-2431054 [Staphylococcus aureus subsp. aureus SA957]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T30123 NC_022442:c2431320-2431054 [Staphylococcus aureus subsp. aureus SA957]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGAAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGTTATTATAGTAGACGTATCAATCACGAACATAGATTGGTCTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT30123 WP_000584499.1 NC_022442:c2431571-2431320 [Staphylococcus aureus subsp. aureus SA957]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT30123 NC_022442:c2431571-2431320 [Staphylococcus aureus subsp. aureus SA957]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACCTCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAATCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGAAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S6D1N9

Antitoxin

Source ID Structure
AlphaFold DB T1YB60

References