Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 1561066..1561480 Replicon chromosome
Accession NC_022442
Organism Staphylococcus aureus subsp. aureus SA957

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag SA957_RS07535 Protein ID WP_001065099.1
Coordinates 1561229..1561480 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag SA957_RS15060 Protein ID WP_000028424.1
Coordinates 1561066..1561239 (-) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SA957_RS07480 1556848..1557192 - 345 WP_000402904.1 hypothetical protein -
SA957_RS07485 1557323..1557622 - 300 WP_000988330.1 HNH endonuclease -
SA957_RS07490 1557854..1558270 - 417 WP_000590122.1 hypothetical protein -
SA957_RS07495 1558298..1558498 - 201 WP_000265043.1 DUF1514 family protein -
SA957_RS07500 1558498..1559148 - 651 WP_001005262.1 hypothetical protein -
SA957_RS07505 1559307..1559456 - 150 WP_000237868.1 transcriptional activator RinB -
SA957_RS07510 1559459..1559659 - 201 WP_001125015.1 hypothetical protein -
SA957_RS07515 1559634..1559822 - 189 WP_000195782.1 DUF1381 domain-containing protein -
SA957_RS07520 1559819..1560064 - 246 WP_001282074.1 hypothetical protein -
SA957_RS07525 1560101..1560607 - 507 WP_001061834.1 dUTPase -
SA957_RS15055 1560622..1560783 - 162 WP_000889683.1 hypothetical protein -
SA957_RS07530 1560784..1561065 - 282 WP_000454994.1 hypothetical protein -
SA957_RS15060 1561066..1561239 - 174 WP_000028424.1 hypothetical protein Antitoxin
SA957_RS07535 1561229..1561480 - 252 WP_001065099.1 DUF1024 family protein Toxin
SA957_RS07540 1561495..1561737 - 243 WP_000131388.1 phi PVL orf 51-like protein -
SA957_RS07545 1561741..1562097 - 357 WP_000029366.1 hypothetical protein -
SA957_RS07550 1562098..1562283 - 186 WP_001187236.1 DUF3113 family protein -
SA957_RS07555 1562288..1562692 - 405 WP_021758092.1 DUF1064 domain-containing protein -
SA957_RS07560 1562702..1562923 - 222 WP_001123669.1 DUF3269 family protein -
SA957_RS07565 1562936..1563094 - 159 WP_000256594.1 hypothetical protein -
SA957_RS07570 1563088..1563867 - 780 WP_021758094.1 ATP-binding protein -
SA957_RS07575 1563877..1564647 - 771 WP_021758096.1 conserved phage C-terminal domain-containing protein -
SA957_RS07580 1564713..1564994 + 282 WP_000414755.1 hypothetical protein -
SA957_RS15065 1564987..1565136 - 150 WP_001081076.1 hypothetical protein -
SA957_RS07585 1565133..1565807 - 675 WP_000057262.1 hypothetical protein -
SA957_RS07590 1565819..1566262 - 444 WP_001099007.1 single-stranded DNA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - lukF-PV / lukS-PV 1533446..1593338 59892


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9376.32 Da        Isoelectric Point: 3.8364

>T30118 WP_001065099.1 NC_022442:c1561480-1561229 [Staphylococcus aureus subsp. aureus SA957]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILKGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T30118 NC_022442:c1561480-1561229 [Staphylococcus aureus subsp. aureus SA957]
ATGAATAACCGCGAACAAATTGAACAGTCCGTTATAAGTGCTAGTGCGTATAACGGCAATGACACAGAGGGATTACTAAA
AGAGATTGAGGACGTGTATAAGAAAGCGCAAGCGTTTGATGAAATACTTAAGGGTTTACCTAATGCTATGCAAGATGCAC
TCAAAGAAGATATTGGTCTTGATGAAGCAGTAGGGATTATGACGGGGCAAGTGGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6468.29 Da        Isoelectric Point: 4.2484

>AT30118 WP_000028424.1 NC_022442:c1561239-1561066 [Staphylococcus aureus subsp. aureus SA957]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT30118 NC_022442:c1561239-1561066 [Staphylococcus aureus subsp. aureus SA957]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCTGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References