Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2167538..2168040 Replicon chromosome
Accession NC_022364
Organism Escherichia coli LY180

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag LY180_RS10825 Protein ID WP_000767829.1
Coordinates 2167538..2167792 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag LY180_RS10830 Protein ID WP_001259255.1
Coordinates 2167789..2168040 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LY180_RS10800 2162553..2162780 - 228 WP_000985273.1 sulfurtransferase TusA family protein -
LY180_RS10805 2162794..2163852 - 1059 WP_000492346.1 transport protein YeeE -
LY180_RS10810 2164031..2165389 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
LY180_RS26340 2165379..2165441 - 63 WP_010723108.1 membrane protein YoeI -
LY180_RS10815 2165656..2166585 - 930 WP_000803351.1 LysR family transcriptional regulator -
LY180_RS10820 2166631..2167455 - 825 WP_000754749.1 SDR family oxidoreductase -
LY180_RS10825 2167538..2167792 - 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
LY180_RS10830 2167789..2168040 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
LY180_RS24800 2168323..2168373 + 51 WP_001364200.1 his operon leader peptide -
LY180_RS10835 2168519..2169418 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
LY180_RS10840 2169424..2170728 + 1305 WP_001349967.1 histidinol dehydrogenase -
LY180_RS10845 2170725..2171795 + 1071 WP_000108957.1 histidinol-phosphate transaminase -
LY180_RS10850 2171795..2172862 + 1068 WP_000080093.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T30100 WP_000767829.1 NC_022364:c2167792-2167538 [Escherichia coli LY180]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T30100 NC_022364:c2167792-2167538 [Escherichia coli LY180]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT30100 WP_001259255.1 NC_022364:c2168040-2167789 [Escherichia coli LY180]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT30100 NC_022364:c2168040-2167789 [Escherichia coli LY180]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References