30058

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2970488..2971136 Replicon chromosome
Accession NC_022350
Organism Mycobacterium tuberculosis str. Haarlem

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag TBHG_RS13935 Protein ID WP_003899414.1
Coordinates 2970488..2970811 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag TBHG_RS13940 Protein ID WP_003899415.1
Coordinates 2970891..2971136 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TBHG_RS13905 2965811..2966809 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
TBHG_RS13910 2966823..2967287 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
TBHG_RS13915 2967275..2967526 + 252 WP_003908028.1 hypothetical protein -
TBHG_RS13920 2967697..2969136 - 1440 WP_003899411.1 phage major capsid protein -
TBHG_RS13925 2969144..2969677 - 534 WP_003899412.1 HK97 family phage prohead protease -
TBHG_RS21520 2969830..2970321 - 492 WP_003900541.1 phage terminase small subunit P27 family -
TBHG_RS13935 2970488..2970811 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
TBHG_RS13940 2970891..2971136 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
TBHG_RS13945 2971133..2972560 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
TBHG_RS13950 2972562..2972954 - 393 WP_003899417.1 DUF2742 domain-containing protein -
TBHG_RS13955 2972951..2973211 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
TBHG_RS13960 2973228..2973590 - 363 WP_003900543.1 hypothetical protein -
TBHG_RS13965 2973593..2974720 - 1128 WP_003899420.1 site-specific integrase -
TBHG_RS13970 2974865..2975092 - 228 WP_003899421.1 hypothetical protein -
TBHG_RS21525 2975089..2975478 - 390 WP_003899422.1 hypothetical protein -
TBHG_RS13975 2975384..2975656 + 273 WP_003900544.1 hypothetical protein -
TBHG_RS13980 2975755..2975988 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2965811..2974720 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T30058 WP_003899414.1 NC_022350:c2970811-2970488 [Mycobacterium tuberculosis str. Haarlem]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T30058 NC_022350:c2970811-2970488 [Mycobacterium tuberculosis str. Haarlem]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT30058 WP_003899415.1 NC_022350:c2971136-2970891 [Mycobacterium tuberculosis str. Haarlem]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT30058 NC_022350:c2971136-2970891 [Mycobacterium tuberculosis str. Haarlem]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References