Detailed information of TA system TA029998

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/Tad-couple_hipB
• Location: 1433668..1434319
• Replicon: chromosome
• Accession: NC_022245
• Organism: Streptococcus constellatus subsp. pharyngis C818

Toxin (Protein)

• Gene name: higB
• Uniprot ID: F9P6Y3
• Locus tag: SCR2_RS07075
• Protein ID: WP_006268450.1
• Coordinates: 1433954..1434319 (-)
• Length: 122 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: SCR2_RS07070
• Protein ID: WP_020997975.1
• Coordinates: 1433668..1433964 (-)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SCR2_RS07055	1429236..1429832	-	597	WP_006268506.1	recombination mediator RecR	-
SCR2_RS07060	1429843..1431903	-	2061	WP_020997973.1	penicillin-binding protein PBP2B	-
SCR2_RS10480	1432267..1432434	-	168	WP_006268192.1	hypothetical protein	-
SCR2_RS07065	1432441..1433646	-	1206	WP_020997974.1	hypothetical protein	-
SCR2_RS07070	1433668..1433964	-	297	WP_020997975.1	helix-turn-helix transcriptional regulator	Antitoxin
SCR2_RS07075	1433954..1434319	-	366	WP_006268450.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SCR2_RS07080	1434385..1434660	-	276	WP_006268376.1	terminase small subunit	-
SCR2_RS07085	1434740..1434970	-	231	WP_022525741.1	hypothetical protein	-
SCR2_RS07090	1435209..1435619	-	411	WP_006268286.1	hypothetical protein	-
SCR2_RS07095	1435600..1436082	-	483	WP_006268241.1	hypothetical protein	-
SCR2_RS09760	1436101..1436481	-	381	WP_006268172.1	hypothetical protein	-
SCR2_RS09765	1436506..1436715	-	210	WP_006268092.1	hypothetical protein	-
SCR2_RS10485	1436795..1436971	-	177	WP_006267997.1	hypothetical protein	-
SCR2_RS07105	1437291..1437782	-	492	WP_020997976.1	hypothetical protein	-
SCR2_RS07110	1438101..1438955	-	855	WP_006268118.1	ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (35-109)

Antitoxin

• Cro/C1-type helix-turn-helix domain (33-88)

Sequences

Toxin

Protein

• Length: 122 a.a.
• Molecular weight: 14448.63 Da
• Isoelectric Point: 9.7920

>T29998 WP_006268450.1 NC_022245:c1434319-1433954 [Streptococcus constellatus subsp. pharyngis C818]
VHNIYFYKDKNGNEPILDYMRELASKKGKDSRIKLNKINDYIELLSQHGTRTGEPYIKHLDAEIWELRPLRDRILFVAWI
DGSFVLLHHFMKKTQKTPKREIEQAKRELADLKERGLDNEK

Nucleotide

• Length: 366 bp

>T29998 NC_022245:c1434319-1433954 [Streptococcus constellatus subsp. pharyngis C818]
GTGCATAATATCTATTTTTACAAGGATAAAAACGGTAATGAGCCTATTTTAGATTATATGCGAGAGCTTGCCAGTAAAAA
GGGAAAAGATAGTAGAATTAAACTCAATAAAATCAATGATTATATTGAGTTGTTAAGTCAACACGGAACACGCACAGGCG
AGCCATATATTAAGCATTTAGATGCTGAAATTTGGGAACTAAGACCATTAAGGGATAGAATTTTATTTGTTGCATGGATT
GATGGTAGCTTTGTTTTACTCCATCATTTCATGAAAAAGACACAGAAAACACCAAAAAGAGAGATTGAACAAGCTAAACG
TGAGTTAGCAGACTTAAAAGAAAGAGGTTTAGACAATGAAAAATAG

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 10755.42 Da
• Isoelectric Point: 4.8898

>AT29998 WP_020997975.1 NC_022245:c1433964-1433668 [Streptococcus constellatus subsp. pharyngis C818]
MKNSAIGSNWKDVRAELFSKEEILESDMRVAIMSELIEARNERGISQKKLEELSGVSQPVIARMETGKTSPQLDTVLKVL
ASLGKTLAVVPLEGEQIS

Nucleotide

• Length: 297 bp

>AT29998 NC_022245:c1433964-1433668 [Streptococcus constellatus subsp. pharyngis C818]
ATGAAAAATAGTGCAATTGGTAGTAACTGGAAAGATGTAAGAGCTGAGTTATTCAGCAAAGAAGAAATTTTAGAAAGTGA
TATGCGTGTGGCTATCATGAGTGAGCTTATCGAGGCTAGGAATGAAAGGGGTATTAGTCAGAAAAAACTAGAGGAGCTGA
GTGGTGTTAGTCAGCCAGTCATAGCTAGAATGGAGACAGGAAAAACAAGCCCACAGCTTGATACCGTTTTAAAAGTATTA
GCAAGTCTTGGTAAGACGTTGGCTGTTGTACCCTTAGAGGGCGAACAGATAAGCTAG

Structures

Toxin

• AlphaFold DB: F9P6Y3