Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-couple_hipB
Location 1354592..1355243 Replicon chromosome
Accession NC_022244
Organism Streptococcus anginosus C1051

Toxin (Protein)


Gene name higB Uniprot ID A0A0P0NA83
Locus tag SAIN_RS06660 Protein ID WP_003023734.1
Coordinates 1354878..1355243 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0P0NA18
Locus tag SAIN_RS06655 Protein ID WP_003023736.1
Coordinates 1354592..1354888 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAIN_RS06640 1350161..1350757 - 597 WP_021001926.1 recombination mediator RecR -
SAIN_RS06645 1350768..1352828 - 2061 WP_021001927.1 penicillin-binding protein PBP2B -
SAIN_RS09925 1353191..1353358 - 168 WP_003023739.1 hypothetical protein -
SAIN_RS06650 1353365..1354570 - 1206 WP_003023737.1 hypothetical protein -
SAIN_RS06655 1354592..1354888 - 297 WP_003023736.1 helix-turn-helix transcriptional regulator Antitoxin
SAIN_RS06660 1354878..1355243 - 366 WP_003023734.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SAIN_RS06665 1355518..1355697 - 180 WP_106079412.1 hypothetical protein -
SAIN_RS06670 1356035..1356562 + 528 Protein_1281 site-specific integrase -
SAIN_RS06675 1356720..1357412 - 693 WP_003023729.1 phosphoglycerate mutase -
SAIN_RS06680 1357553..1358014 - 462 WP_021001929.1 transcriptional repressor -
SAIN_RS06685 1358191..1358466 - 276 WP_003023726.1 HU family DNA-binding protein -
SAIN_RS06690 1358595..1359428 - 834 WP_003023725.1 DegV family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(35-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-88)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 14583.84 Da        Isoelectric Point: 10.1543

>T29997 WP_003023734.1 NC_022244:c1355243-1354878 [Streptococcus anginosus C1051]
VHNIYFYKDKNGNEPVLDYMRELASKKGKDSRIKLNKINDYIELLSQRGTRAGEPYIKHLDAEIWELRPLRDRILFVAWI
DGNFVLLHHFMKKTQKTPKREIEQAKRELRDLKERGLYNEK

Download         Length: 366 bp

>T29997 NC_022244:c1355243-1354878 [Streptococcus anginosus C1051]
GTGCATAATATCTATTTTTACAAAGATAAAAACGGGAATGAGCCGGTTTTAGATTATATGCGTGAACTTGCCAGCAAAAA
AGGCAAGGATAGTCGTATCAAACTAAACAAGATAAATGACTATATCGAACTACTAAGCCAACGTGGTACACGCGCAGGAG
AACCGTATATTAAGCATTTAGATGCTGAAATTTGGGAGCTTAGACCATTGAGGGATAGGATATTATTTGTTGCTTGGATT
GATGGCAACTTTGTATTGTTGCATCATTTTATGAAAAAGACGCAGAAAACACCAAAACGAGAAATTGAACAAGCAAAGCG
TGAATTACGCGACTTAAAAGAAAGAGGGCTATACAATGAAAAATAG

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10699.35 Da        Isoelectric Point: 4.8780

>AT29997 WP_003023736.1 NC_022244:c1354888-1354592 [Streptococcus anginosus C1051]
MKNSAIGSNWKDVRAELFSKEEILESDMRVAIMSELIDARNEKGISQKKLEELSGVSQPVIARMETGKTSPQLDTVLKVL
ASLGKTLAVVPLEGEQVS

Download         Length: 297 bp

>AT29997 NC_022244:c1354888-1354592 [Streptococcus anginosus C1051]
ATGAAAAATAGTGCAATTGGTAGTAACTGGAAAGATGTGAGAGCTGAACTTTTTTCCAAAGAGGAAATTTTGGAGAGTGA
TATGCGCGTGGCAATCATGAGTGAGCTGATTGATGCTAGAAATGAAAAAGGGATCAGTCAGAAAAAACTTGAGGAACTAA
GCGGAGTAAGTCAGCCAGTTATTGCTAGAATGGAAACAGGTAAGACAAGTCCACAACTTGATACTGTTTTAAAAGTCTTG
GCAAGTCTTGGGAAAACTTTGGCAGTTGTACCCTTAGAGGGCGAACAGGTAAGCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0P0NA83

Antitoxin

Source ID Structure
AlphaFold DB A0A0P0NA18

References