Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 131068..131581 Replicon chromosome
Accession NC_022244
Organism Streptococcus anginosus C1051

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0N7JDI1
Locus tag SAIN_RS00745 Protein ID WP_003027142.1
Coordinates 131068..131322 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0P0N6Y5
Locus tag SAIN_RS00750 Protein ID WP_003027139.1
Coordinates 131315..131581 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAIN_RS09785 128817..128936 - 120 Protein_106 site-specific integrase -
SAIN_RS00725 129424..129681 + 258 WP_003027150.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
SAIN_RS00730 129678..130034 + 357 Protein_108 type II toxin-antitoxin system death-on-curing family toxin -
SAIN_RS00735 130144..130419 - 276 Protein_109 helix-turn-helix transcriptional regulator -
SAIN_RS00740 130406..130786 - 381 WP_003027145.1 type II toxin-antitoxin system RelE/ParE family toxin -
SAIN_RS00745 131068..131322 - 255 WP_003027142.1 Txe/YoeB family addiction module toxin Toxin
SAIN_RS00750 131315..131581 - 267 WP_003027139.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
SAIN_RS00755 132098..133495 + 1398 WP_021001204.1 MucBP domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10455.90 Da        Isoelectric Point: 9.2753

>T29996 WP_003027142.1 NC_022244:c131322-131068 [Streptococcus anginosus C1051]
MFNFTEQAWKDYVSWQQEDKKILKRINRLIEDIKRNPFEGIGKPEPLKYRYSGAWSRRITDEQRLVYMVEKDEIYFLSFR
DHYT

Download         Length: 255 bp

>T29996 NC_022244:c131322-131068 [Streptococcus anginosus C1051]
ATGTTTAACTTTACAGAACAAGCTTGGAAAGATTATGTTTCTTGGCAACAAGAGGATAAAAAGATACTCAAACGTATCAA
TCGTTTAATAGAGGATATCAAACGGAATCCTTTTGAAGGGATTGGAAAGCCTGAACCCTTAAAATATCGTTATTCCGGTG
CTTGGTCTCGTAGAATTACAGATGAACAACGATTAGTCTATATGGTGGAAAAAGATGAGATTTATTTCTTATCCTTTAGA
GACCATTACACATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10475.03 Da        Isoelectric Point: 5.8648

>AT29996 WP_003027139.1 NC_022244:c131581-131315 [Streptococcus anginosus C1051]
MEAVVYSNFRNNLKHYMKKVNDEYEPLMVVNKNPDENIVVLSKKNWDSIQETIRLMNNEYLSDKVLSGMEQVKQKKTIQR
QLLEVEDV

Download         Length: 267 bp

>AT29996 NC_022244:c131581-131315 [Streptococcus anginosus C1051]
ATGGAAGCTGTCGTCTATTCAAATTTTAGAAACAATTTAAAACATTACATGAAAAAAGTCAACGATGAATATGAACCTCT
AATGGTTGTCAATAAAAATCCTGATGAAAATATTGTAGTCTTATCTAAGAAAAATTGGGATAGTATCCAAGAAACCATCC
GTCTAATGAATAACGAGTACCTTTCAGACAAGGTTCTATCAGGAATGGAACAAGTCAAGCAAAAGAAAACCATTCAACGC
CAATTATTAGAGGTGGAAGATGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0N7JDI1

Antitoxin

Source ID Structure
AlphaFold DB A0A0P0N6Y5

References