Detailed information of TA system TA029989

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 138164..138677
• Replicon: chromosome
• Accession: NC_022239
• Organism: Streptococcus anginosus C238

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: I0SIM6
• Locus tag: SANR_RS00800
• Protein ID: WP_003034719.1
• Coordinates: 138164..138418 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: I0SIL5
• Locus tag: SANR_RS00805
• Protein ID: WP_003034688.1
• Coordinates: 138411..138677 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SANR_RS00765	134043..134459	-	417	WP_020999431.1	conjugal transfer protein	-
SANR_RS00770	134461..134688	-	228	WP_002271001.1	hypothetical protein	-
SANR_RS00775	134705..135697	-	993	WP_003034679.1	conjugal transfer protein	-
SANR_RS00780	135707..136261	-	555	WP_003034624.1	hypothetical protein	-
SANR_RS00785	136258..136494	-	237	WP_000456039.1	hypothetical protein	-
SANR_RS00790	136514..136900	-	387	WP_003034694.1	hypothetical protein	-
SANR_RS00795	136878..138110	-	1233	WP_025272020.1	replication initiation factor domain-containing protein	-
SANR_RS00800	138164..138418	-	255	WP_003034719.1	Txe/YoeB family addiction module toxin	Toxin
SANR_RS00805	138411..138677	-	267	WP_003034688.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
SANR_RS00810	138941..140599	-	1659	WP_003034653.1	cell division protein FtsK	-
SANR_RS00815	140606..141016	-	411	WP_003034661.1	DUF961 family protein	-
SANR_RS00820	141039..141353	-	315	WP_000406626.1	hypothetical protein	-
SANR_RS00825	141468..141695	-	228	WP_003034721.1	hypothetical protein	-
SANR_RS00830	141692..141928	-	237	WP_003034655.1	hypothetical protein	-
SANR_RS00835	142057..142335	-	279	WP_003034637.1	type II toxin-antitoxin system YafQ family toxin	-
SANR_RS00840	142336..142608	-	273	WP_003034600.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
SANR_RS00845	143281..143643	+	363	WP_003034723.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	126809..149107	22298

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (4-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10509.97 Da
• Isoelectric Point: 9.2761

>T29989 WP_003034719.1 NC_022239:c138418-138164 [Streptococcus anginosus C238]
MFNFTEQAWKDYVSWQQEDKKILKRINRLMEDIKRNPFEGIGKPEPLKYRYSGAWSRRITDEHRLVYMVEENEIYFLSFR
DHYK

Nucleotide

• Length: 255 bp

>T29989 NC_022239:c138418-138164 [Streptococcus anginosus C238]
ATGTTTAACTTTACAGAACAAGCTTGGAAAGATTATGTTTCTTGGCAACAAGAAGATAAAAAGATACTCAAACGTATCAA
TCGTTTAATGGAGGATATCAAACGAAATCCTTTTGAAGGGATTGGAAAGCCTGAACCCTTAAAATACCGTTATTCCGGTG
CTTGGTCTCGTAGAATTACAGATGAACACCGATTAGTCTATATGGTGGAAGAAAATGAGATTTATTTCTTATCCTTTCGA
GACCACTATAAATAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10405.92 Da
• Isoelectric Point: 4.6437

>AT29989 WP_003034688.1 NC_022239:c138677-138411 [Streptococcus anginosus C238]
MEAVVYSNFRNNLKNYMKKVNDEYEPLMVVNKNPDENIVVLSKENWDSIQETIRLMNNDYLSDKVLSGMEQVKQKKVIQR
PLLEVEDV

Nucleotide

• Length: 267 bp

>AT29989 NC_022239:c138677-138411 [Streptococcus anginosus C238]
ATGGAAGCTGTCGTCTATTCAAATTTTAGAAACAATTTAAAGAATTACATGAAAAAAGTCAACGATGAATATGAACCTCT
AATGGTTGTCAATAAAAATCCTGATGAAAATATTGTGGTCTTATCTAAGGAAAACTGGGATAGTATTCAAGAAACCATTC
GCCTAATGAATAATGATTATCTTTCAGACAAGGTTCTATCAGGAATGGAACAAGTCAAGCAAAAGAAAGTCATTCAACGC
CCATTATTAGAGGTGGAAGATGTTTAA

Structures

Toxin

• AlphaFold DB: I0SIM6

Antitoxin

• AlphaFold DB: I0SIL5