Detailed information of TA system TA029988

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/Tad-couple_hipB
• Location: 1489398..1490049
• Replicon: chromosome
• Accession: NC_022238
• Organism: Streptococcus constellatus subsp. pharyngis C1050

Toxin (Protein)

• Gene name: higB
• Uniprot ID: F9P6Y3
• Locus tag: SCI_RS07320
• Protein ID: WP_006268450.1
• Coordinates: 1489684..1490049 (-)
• Length: 122 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: SCI_RS07315
• Protein ID: WP_020997975.1
• Coordinates: 1489398..1489694 (-)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SCI_RS07300	1484966..1485562	-	597	WP_006268506.1	recombination mediator RecR	-
SCI_RS07305	1485573..1487633	-	2061	WP_020997973.1	penicillin-binding protein PBP2B	-
SCI_RS10710	1487997..1488164	-	168	WP_006268192.1	hypothetical protein	-
SCI_RS07310	1488171..1489376	-	1206	WP_020997974.1	hypothetical protein	-
SCI_RS07315	1489398..1489694	-	297	WP_020997975.1	helix-turn-helix transcriptional regulator	Antitoxin
SCI_RS07320	1489684..1490049	-	366	WP_006268450.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SCI_RS07325	1490115..1490390	-	276	WP_006268376.1	terminase small subunit	-
SCI_RS07330	1490470..1490700	-	231	WP_022525741.1	hypothetical protein	-
SCI_RS07335	1490939..1491349	-	411	WP_006268286.1	hypothetical protein	-
SCI_RS07340	1491330..1491812	-	483	WP_006268241.1	hypothetical protein	-
SCI_RS10010	1491831..1492211	-	381	WP_006268172.1	hypothetical protein	-
SCI_RS10015	1492236..1492445	-	210	WP_006268092.1	hypothetical protein	-
SCI_RS10715	1492525..1492701	-	177	WP_006267997.1	hypothetical protein	-
SCI_RS07350	1493021..1493512	-	492	WP_006268458.1	hypothetical protein	-
SCI_RS07355	1493831..1494685	-	855	WP_006268118.1	ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1484966..1506188	21222

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (35-109)

Antitoxin

• Cro/C1-type helix-turn-helix domain (33-88)

Sequences

Toxin

Protein

• Length: 122 a.a.
• Molecular weight: 14448.63 Da
• Isoelectric Point: 9.7920

>T29988 WP_006268450.1 NC_022238:c1490049-1489684 [Streptococcus constellatus subsp. pharyngis C1050]
VHNIYFYKDKNGNEPILDYMRELASKKGKDSRIKLNKINDYIELLSQHGTRTGEPYIKHLDAEIWELRPLRDRILFVAWI
DGSFVLLHHFMKKTQKTPKREIEQAKRELADLKERGLDNEK

Nucleotide

• Length: 366 bp

>T29988 NC_022238:c1490049-1489684 [Streptococcus constellatus subsp. pharyngis C1050]
GTGCATAATATCTATTTTTACAAGGATAAAAACGGTAATGAGCCTATTTTAGATTATATGCGAGAGCTTGCCAGTAAAAA
GGGAAAAGATAGTAGAATTAAACTCAATAAAATCAATGATTATATTGAGTTGTTAAGTCAACACGGAACACGCACAGGCG
AGCCATATATTAAGCATTTAGATGCTGAAATTTGGGAACTAAGACCATTAAGGGATAGAATTTTATTTGTTGCATGGATT
GATGGTAGCTTTGTTTTACTCCATCATTTCATGAAAAAGACACAGAAAACACCAAAAAGAGAGATTGAACAAGCTAAACG
TGAGTTAGCAGACTTAAAAGAAAGAGGTTTAGACAATGAAAAATAG

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 10755.42 Da
• Isoelectric Point: 4.8898

>AT29988 WP_020997975.1 NC_022238:c1489694-1489398 [Streptococcus constellatus subsp. pharyngis C1050]
MKNSAIGSNWKDVRAELFSKEEILESDMRVAIMSELIEARNERGISQKKLEELSGVSQPVIARMETGKTSPQLDTVLKVL
ASLGKTLAVVPLEGEQIS

Nucleotide

• Length: 297 bp

>AT29988 NC_022238:c1489694-1489398 [Streptococcus constellatus subsp. pharyngis C1050]
ATGAAAAATAGTGCAATTGGTAGTAACTGGAAAGATGTAAGAGCTGAGTTATTCAGCAAAGAAGAAATTTTAGAAAGTGA
TATGCGTGTGGCTATCATGAGTGAGCTTATCGAGGCTAGGAATGAAAGGGGTATTAGTCAGAAAAAACTAGAGGAGCTGA
GTGGTGTTAGTCAGCCAGTCATAGCTAGAATGGAGACAGGAAAAACAAGCCCACAGCTTGATACCGTTTTAAAAGTATTA
GCAAGTCTTGGTAAGACGTTGGCTGTTGTACCCTTAGAGGGCGAACAGATAAGCTAG

Structures

Toxin

• AlphaFold DB: F9P6Y3