Detailed information of TA system TA029986

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/Tad-couple_hipB
• Location: 1433419..1434070
• Replicon: chromosome
• Accession: NC_022236
• Organism: Streptococcus constellatus subsp. pharyngis C232

Toxin (Protein)

• Gene name: higB
• Uniprot ID: F9P6Y3
• Locus tag: SCRE_RS07080
• Protein ID: WP_006268450.1
• Coordinates: 1433705..1434070 (-)
• Length: 122 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: SCRE_RS07075
• Protein ID: WP_020997975.1
• Coordinates: 1433419..1433715 (-)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SCRE_RS07060	1428987..1429583	-	597	WP_006268506.1	recombination mediator RecR	-
SCRE_RS07065	1429594..1431654	-	2061	WP_020997973.1	penicillin-binding protein PBP2B	-
SCRE_RS10475	1432018..1432185	-	168	WP_006268192.1	hypothetical protein	-
SCRE_RS07070	1432192..1433397	-	1206	WP_020997974.1	hypothetical protein	-
SCRE_RS07075	1433419..1433715	-	297	WP_020997975.1	helix-turn-helix transcriptional regulator	Antitoxin
SCRE_RS07080	1433705..1434070	-	366	WP_006268450.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SCRE_RS07085	1434136..1434411	-	276	WP_006268376.1	terminase small subunit	-
SCRE_RS07090	1434491..1434721	-	231	WP_022525741.1	hypothetical protein	-
SCRE_RS07095	1434960..1435370	-	411	WP_006268286.1	hypothetical protein	-
SCRE_RS07100	1435351..1435833	-	483	WP_006268241.1	hypothetical protein	-
SCRE_RS09765	1435852..1436232	-	381	WP_006268172.1	hypothetical protein	-
SCRE_RS09770	1436257..1436466	-	210	WP_006268092.1	hypothetical protein	-
SCRE_RS10480	1436546..1436722	-	177	WP_006267997.1	hypothetical protein	-
SCRE_RS07110	1437042..1437533	-	492	WP_020997976.1	hypothetical protein	-
SCRE_RS07115	1437852..1438706	-	855	WP_006268118.1	ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1428987..1444563	15576

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (35-109)

Antitoxin

• Cro/C1-type helix-turn-helix domain (33-88)

Sequences

Toxin

Protein

• Length: 122 a.a.
• Molecular weight: 14448.63 Da
• Isoelectric Point: 9.7920

>T29986 WP_006268450.1 NC_022236:c1434070-1433705 [Streptococcus constellatus subsp. pharyngis C232]
VHNIYFYKDKNGNEPILDYMRELASKKGKDSRIKLNKINDYIELLSQHGTRTGEPYIKHLDAEIWELRPLRDRILFVAWI
DGSFVLLHHFMKKTQKTPKREIEQAKRELADLKERGLDNEK

Nucleotide

• Length: 366 bp

>T29986 NC_022236:c1434070-1433705 [Streptococcus constellatus subsp. pharyngis C232]
GTGCATAATATCTATTTTTACAAGGATAAAAACGGTAATGAGCCTATTTTAGATTATATGCGAGAGCTTGCCAGTAAAAA
GGGAAAAGATAGTAGAATTAAACTCAATAAAATCAATGATTATATTGAGTTGTTAAGTCAACACGGAACACGCACAGGCG
AGCCATATATTAAGCATTTAGATGCTGAAATTTGGGAACTAAGACCATTAAGGGATAGAATTTTATTTGTTGCATGGATT
GATGGTAGCTTTGTTTTACTCCATCATTTCATGAAAAAGACACAGAAAACACCAAAAAGAGAGATTGAACAAGCTAAACG
TGAGTTAGCAGACTTAAAAGAAAGAGGTTTAGACAATGAAAAATAG

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 10755.42 Da
• Isoelectric Point: 4.8898

>AT29986 WP_020997975.1 NC_022236:c1433715-1433419 [Streptococcus constellatus subsp. pharyngis C232]
MKNSAIGSNWKDVRAELFSKEEILESDMRVAIMSELIEARNERGISQKKLEELSGVSQPVIARMETGKTSPQLDTVLKVL
ASLGKTLAVVPLEGEQIS

Nucleotide

• Length: 297 bp

>AT29986 NC_022236:c1433715-1433419 [Streptococcus constellatus subsp. pharyngis C232]
ATGAAAAATAGTGCAATTGGTAGTAACTGGAAAGATGTAAGAGCTGAGTTATTCAGCAAAGAAGAAATTTTAGAAAGTGA
TATGCGTGTGGCTATCATGAGTGAGCTTATCGAGGCTAGGAATGAAAGGGGTATTAGTCAGAAAAAACTAGAGGAGCTGA
GTGGTGTTAGTCAGCCAGTCATAGCTAGAATGGAGACAGGAAAAACAAGCCCACAGCTTGATACCGTTTTAAAAGTATTA
GCAAGTCTTGGTAAGACGTTGGCTGTTGTACCCTTAGAGGGCGAACAGATAAGCTAG

Structures

Toxin

• AlphaFold DB: F9P6Y3