Detailed information of TA system TA029983

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2466652..2467175
• Replicon: chromosome
• Accession: NC_022226
• Organism: Staphylococcus aureus subsp. aureus CN1

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: T1YCD0
• Locus tag: SAKOR_RS12535
• Protein ID: WP_000074043.1
• Coordinates: 2466652..2466918 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YBB2
• Locus tag: SAKOR_RS12540
• Protein ID: WP_000587618.1
• Coordinates: 2466918..2467175 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAKOR_RS12515	2461958..2463145	-	1188	WP_000026187.1	MFS transporter	-
SAKOR_RS12520	2463541..2464317	-	777	WP_000072147.1	iron export ABC transporter permease subunit FetB	-
SAKOR_RS12525	2464310..2464972	-	663	WP_000923524.1	ATP-binding cassette domain-containing protein	-
SAKOR_RS12530	2465220..2466296	-	1077	WP_001076665.1	M42 family metallopeptidase	-
SAKOR_RS12535	2466652..2466918	-	267	WP_000074043.1	Txe/YoeB family addiction module toxin	Toxin
SAKOR_RS12540	2466918..2467175	-	258	WP_000587618.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
SAKOR_RS12550	2467535..2467990	+	456	WP_000732082.1	DUF1307 domain-containing protein	-
SAKOR_RS12555	2468158..2469735	-	1578	WP_000143508.1	FMN-binding glutamate synthase family protein	-
SAKOR_RS12560	2469931..2470680	+	750	WP_000072441.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (4-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10657.45 Da
• Isoelectric Point: 10.3584

>T29983 WP_000074043.1 NC_022226:c2466918-2466652 [Staphylococcus aureus subsp. aureus CN1]
MSNYTVKIKNSAKLDLKKIKHPYLKKTFIEIVETLKNNPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLI
LSAWSHYD

Nucleotide

• Length: 267 bp

>T29983 NC_022226:c2466918-2466652 [Staphylococcus aureus subsp. aureus CN1]
ATGAGCAATTACACGGTTAAGATTAAAAATTCGGCGAAGTTAGATTTAAAGAAAATAAAACATCCTTATTTAAAGAAGAC
ATTTATAGAAATTGTTGAGACTTTAAAAAATAATCCTTATAAAATAACACAATCCTTTGAAAAATTAGAACCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCTTCAGCACAGGGTCGTCTATACCATAGATGATCGAAATAAAGTAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9762.78 Da
• Isoelectric Point: 4.1958

>AT29983 WP_000587618.1 NC_022226:c2467175-2466918 [Staphylococcus aureus subsp. aureus CN1]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDNSGTTNIDDI
DWDNL

Nucleotide

• Length: 258 bp

>AT29983 NC_022226:c2467175-2466918 [Staphylococcus aureus subsp. aureus CN1]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGTAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATGT
ATCTTGTATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Structures

Toxin

• AlphaFold DB: T1YCD0

Antitoxin

• AlphaFold DB: T1YBB2