Detailed information of TA system TA029981

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2435471..2435655
• Replicon: chromosome
• Accession: NC_022226
• Organism: Staphylococcus aureus subsp. aureus CN1

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: Q2FVI9
• Locus tag: SAKOR_RS12380
• Protein ID: WP_000482650.1
• Coordinates: 2435548..2435655 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2435471..2435531 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAKOR_RS12355	2430981..2431148	-	168	WP_001792506.1	hypothetical protein	-
SAKOR_RS12365	2431379..2433112	-	1734	WP_000486494.1	ABC transporter ATP-binding protein/permease	-
SAKOR_RS12370	2433137..2434900	-	1764	WP_001064820.1	ABC transporter ATP-binding protein/permease	-
-	2435471..2435531	+	61	-	-	Antitoxin
SAKOR_RS12380	2435548..2435655	-	108	WP_000482650.1	type I toxin-antitoxin system Fst family toxin	Toxin
SAKOR_RS12385	2435789..2436175	-	387	WP_000779358.1	flippase GtxA	-
SAKOR_RS12390	2436433..2437575	+	1143	WP_001176863.1	glycerate kinase	-
SAKOR_RS12395	2437635..2438294	+	660	WP_000831298.1	membrane protein	-
SAKOR_RS12400	2438476..2439687	+	1212	WP_001192075.1	multidrug effflux MFS transporter	-
SAKOR_RS12405	2439810..2440283	-	474	WP_000456489.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (8-85)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T29981 WP_000482650.1 NC_022226:c2435655-2435548 [Staphylococcus aureus subsp. aureus CN1]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T29981 NC_022226:c2435655-2435548 [Staphylococcus aureus subsp. aureus CN1]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT29981 NC_022226:2435471-2435531 [Staphylococcus aureus subsp. aureus CN1]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2C9TTS8

Antitoxin