Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2410099..2410616 Replicon chromosome
Accession NC_022226
Organism Staphylococcus aureus subsp. aureus CN1

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag SAKOR_RS12230 Protein ID WP_000113262.1
Coordinates 2410099..2410365 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag SAKOR_RS12235 Protein ID WP_000584499.1
Coordinates 2410365..2410616 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAKOR_RS12205 2405522..2406058 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
SAKOR_RS12210 2406292..2407116 - 825 WP_000572040.1 formate/nitrite transporter family protein -
SAKOR_RS12215 2407333..2407515 - 183 WP_000079142.1 hypothetical protein -
SAKOR_RS12220 2407602..2408069 - 468 WP_000153344.1 SRPBCC domain-containing protein -
SAKOR_RS12225 2408255..2409805 - 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
SAKOR_RS12230 2410099..2410365 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
SAKOR_RS12235 2410365..2410616 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SAKOR_RS12240 2410781..2410882 - 102 Protein_2310 hypothetical protein -
SAKOR_RS12245 2410889..2411488 - 600 WP_000162803.1 DsbA family protein -
SAKOR_RS12250 2411507..2411869 - 363 WP_000819843.1 DUF4467 domain-containing protein -
SAKOR_RS12255 2412124..2413374 + 1251 WP_001012228.1 FemA/FemB family glycyltransferase FmhA -
SAKOR_RS12260 2413471..2414202 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
SAKOR_RS12265 2414199..2414918 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T29980 WP_000113262.1 NC_022226:c2410365-2410099 [Staphylococcus aureus subsp. aureus CN1]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T29980 NC_022226:c2410365-2410099 [Staphylococcus aureus subsp. aureus CN1]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT29980 WP_000584499.1 NC_022226:c2410616-2410365 [Staphylococcus aureus subsp. aureus CN1]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT29980 NC_022226:c2410616-2410365 [Staphylococcus aureus subsp. aureus CN1]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References