Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 2153998..2154214 Replicon chromosome
Accession NC_022226
Organism Staphylococcus aureus subsp. aureus CN1

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag SAKOR_RS10885 Protein ID WP_001802298.1
Coordinates 2154110..2154214 (-) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF1
Locus tag -
Coordinates 2153998..2154053 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAKOR_RS10865 2150201..2150866 - 666 WP_001024095.1 SDR family oxidoreductase -
SAKOR_RS10870 2151018..2151338 + 321 WP_000003755.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
SAKOR_RS10875 2151340..2152320 + 981 WP_000019743.1 CDF family zinc efflux transporter CzrB -
SAKOR_RS10880 2152586..2153677 + 1092 WP_000495681.1 hypothetical protein -
- 2153998..2154053 + 56 - - Antitoxin
SAKOR_RS10885 2154110..2154214 - 105 WP_001802298.1 hypothetical protein Toxin
SAKOR_RS14485 2154894..2155052 + 159 WP_001792784.1 hypothetical protein -
SAKOR_RS10890 2155710..2156567 - 858 WP_000370928.1 Cof-type HAD-IIB family hydrolase -
SAKOR_RS10895 2156635..2157417 - 783 WP_000908189.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-126)


Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T29978 WP_001802298.1 NC_022226:c2154214-2154110 [Staphylococcus aureus subsp. aureus CN1]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T29978 NC_022226:c2154214-2154110 [Staphylococcus aureus subsp. aureus CN1]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 56 bp

>AT29978 NC_022226:2153998-2154053 [Staphylococcus aureus subsp. aureus CN1]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References