Detailed information of TA system TA029973

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 1981056..1981363
• Replicon: chromosome
• Accession: NC_022226
• Organism: Staphylococcus aureus subsp. aureus CN1

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: SAKOR_RS14440
• Protein ID: WP_011447039.1
• Coordinates: 1981187..1981363 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1981056..1981195 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAKOR_RS09875	1976406..1976666	+	261	WP_001791826.1	hypothetical protein	-
SAKOR_RS09880	1976719..1977059	-	341	Protein_1858	complement inhibitor SCIN-A	-
SAKOR_RS09885	1977743..1978192	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
SAKOR_RS14810	1978287..1978622	-	336	Protein_1860	SH3 domain-containing protein	-
SAKOR_RS09895	1979272..1979763	-	492	WP_020978269.1	staphylokinase	-
SAKOR_RS09900	1979954..1980709	-	756	WP_000861038.1	CHAP domain-containing protein	-
SAKOR_RS09905	1980721..1980975	-	255	WP_000611512.1	phage holin	-
SAKOR_RS09910	1981027..1981134	+	108	WP_001791821.1	hypothetical protein	-
-	1981056..1981195	+	140	NuclAT_0	-	Antitoxin
-	1981056..1981195	+	140	NuclAT_0	-	Antitoxin
-	1981056..1981195	+	140	NuclAT_0	-	Antitoxin
-	1981056..1981195	+	140	NuclAT_0	-	Antitoxin
SAKOR_RS14440	1981187..1981363	-	177	WP_011447039.1	putative holin-like toxin	Toxin
SAKOR_RS09920	1981513..1981809	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
SAKOR_RS09925	1981867..1982154	-	288	WP_001040261.1	hypothetical protein	-
SAKOR_RS09930	1982201..1982353	-	153	WP_001153681.1	hypothetical protein	-
SAKOR_RS09935	1982343..1986128	-	3786	WP_000582165.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / scn / chp / sak / hlb / groEL	1976719..2028927	52208

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T29973 WP_011447039.1 NC_022226:c1981363-1981187 [Staphylococcus aureus subsp. aureus CN1]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T29973 NC_022226:c1981363-1981187 [Staphylococcus aureus subsp. aureus CN1]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT29973 NC_022226:1981056-1981195 [Staphylococcus aureus subsp. aureus CN1]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin