Detailed information of TA system TA029970

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1816941..1817121
• Replicon: chromosome
• Accession: NC_022226
• Organism: Staphylococcus aureus subsp. aureus CN1

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: SAKOR_RS14895
• Protein ID: WP_001801861.1
• Coordinates: 1816941..1817036 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1817064..1817121 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAKOR_RS08830	1811983..1812609	+	627	WP_000669021.1	hypothetical protein	-
SAKOR_RS08835	1812650..1812991	+	342	WP_000627547.1	DUF3969 family protein	-
SAKOR_RS08840	1813092..1813663	+	572	Protein_1694	hypothetical protein	-
SAKOR_RS08845	1813861..1814418	-	558	WP_000864139.1	ImmA/IrrE family metallo-endopeptidase	-
SAKOR_RS08855	1814789..1814965	-	177	WP_000375476.1	hypothetical protein	-
SAKOR_RS08860	1814976..1815359	-	384	WP_000070811.1	hypothetical protein	-
SAKOR_RS08865	1816044..1816490	-	447	WP_000747802.1	DUF1433 domain-containing protein	-
SAKOR_RS14895	1816941..1817036	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1817064..1817121	-	58	-	-	Antitoxin
SAKOR_RS08875	1817159..1817260	+	102	WP_001791232.1	hypothetical protein	-
SAKOR_RS14385	1817238..1817420	-	183	Protein_1701	transposase	-
SAKOR_RS08880	1817608..1817982	-	375	WP_000695818.1	DUF1433 domain-containing protein	-
SAKOR_RS08885	1818004..1818351	-	348	WP_001566695.1	DUF1433 domain-containing protein	-
SAKOR_RS08890	1818588..1819004	-	417	WP_020978241.1	DUF1433 domain-containing protein	-
SAKOR_RS08895	1819651..1820769	-	1119	WP_000072558.1	restriction endonuclease subunit S	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukD / hlgA / selk	1787408..1844272	56864
	-	inside	Prophage	-	lukD / hlgA / selk	1791126..1846940	55814

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T29970 WP_001801861.1 NC_022226:1816941-1817036 [Staphylococcus aureus subsp. aureus CN1]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T29970 NC_022226:1816941-1817036 [Staphylococcus aureus subsp. aureus CN1]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin

Nucleotide

• Length: 58 bp

>AT29970 NC_022226:c1817121-1817064 [Staphylococcus aureus subsp. aureus CN1]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin