Detailed information of TA system TA029964

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2440777..2441300
• Replicon: chromosome
• Accession: NC_022222
• Organism: Staphylococcus aureus subsp. aureus 6850

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: RSAU_RS12320
• Protein ID: WP_042908766.1
• Coordinates: 2440777..2441043 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: RSAU_RS12325
• Protein ID: WP_020977565.1
• Coordinates: 2441043..2441300 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RSAU_RS12300	2435987..2437174	-	1188	WP_000026189.1	MFS transporter	-
RSAU_RS12305	2437570..2438346	-	777	WP_020977563.1	iron export ABC transporter permease subunit FetB	-
RSAU_RS12310	2438339..2439001	-	663	WP_020977564.1	ATP-binding cassette domain-containing protein	-
RSAU_RS12315	2439345..2440421	-	1077	WP_001076676.1	M42 family metallopeptidase	-
RSAU_RS12320	2440777..2441043	-	267	WP_042908766.1	Txe/YoeB family addiction module toxin	Toxin
RSAU_RS12325	2441043..2441300	-	258	WP_020977565.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
RSAU_RS12335	2441659..2442114	+	456	WP_000732085.1	YehR family lipoprotein	-
RSAU_RS12340	2442289..2443866	-	1578	WP_000143488.1	FMN-binding glutamate synthase family protein	-
RSAU_RS12345	2444061..2444810	+	750	WP_020977566.1	hypothetical protein	-
RSAU_RS12350	2445034..2446227	-	1194	WP_000675402.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (28-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10638.34 Da
• Isoelectric Point: 10.0798

>T29964 WP_042908766.1 NC_022222:c2441043-2440777 [Staphylococcus aureus subsp. aureus 6850]
MSNYTVKIKNSAKLDLKKIKHPYLKKTFIEIVETLKNDPCKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Nucleotide

• Length: 267 bp

>T29964 NC_022222:c2441043-2440777 [Staphylococcus aureus subsp. aureus 6850]
ATGAGCAATTACACGGTTAAGATTAAAAATTCGGCGAAGTTAGATTTAAAGAAAATAAAACATCCTTATTTAAAGAAGAC
ATTTATAGAAATTGTTGAGACTTTAAAAAATGATCCTTGTAAAATAACACAATCCTTTGAAAAATTAGAACCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9796.79 Da
• Isoelectric Point: 4.3304

>AT29964 WP_020977565.1 NC_022222:c2441300-2441043 [Staphylococcus aureus subsp. aureus 6850]
MIITSPTEARKHFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Nucleotide

• Length: 258 bp

>AT29964 NC_022222:c2441300-2441043 [Staphylococcus aureus subsp. aureus 6850]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAGCATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTCAGAGAAAGAGAAAAAGATAATAGTGGTACTACAAATATAGACGATATT
GATTGGGATAATCTTTAA