Detailed information of TA system TA029962

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2409461..2409645
• Replicon: chromosome
• Accession: NC_022222
• Organism: Staphylococcus aureus subsp. aureus 6850

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: RSAU_RS12165
• Protein ID: WP_000482647.1
• Coordinates: 2409538..2409645 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2409461..2409521 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RSAU_RS12145	2404971..2405138	-	168	WP_001789205.1	hypothetical protein	-
RSAU_RS12155	2405369..2407102	-	1734	WP_020977552.1	ABC transporter ATP-binding protein/permease	-
RSAU_RS12160	2407127..2408890	-	1764	WP_001064822.1	ABC transporter ATP-binding protein/permease	-
-	2409461..2409521	+	61	-	-	Antitoxin
RSAU_RS12165	2409538..2409645	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
RSAU_RS12170	2409779..2410165	-	387	WP_000779353.1	flippase GtxA	-
RSAU_RS12175	2410433..2411575	+	1143	WP_001176863.1	glycerate kinase	-
RSAU_RS12180	2411635..2412294	+	660	WP_000831298.1	membrane protein	-
RSAU_RS12185	2412477..2413688	+	1212	WP_001191921.1	multidrug effflux MFS transporter	-
RSAU_RS12190	2413811..2414284	-	474	WP_020977553.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-122)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T29962 WP_000482647.1 NC_022222:c2409645-2409538 [Staphylococcus aureus subsp. aureus 6850]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T29962 NC_022222:c2409645-2409538 [Staphylococcus aureus subsp. aureus 6850]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT29962 NC_022222:2409461-2409521 [Staphylococcus aureus subsp. aureus 6850]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin