Detailed information of TA system TA029949

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 664901..665239
• Replicon: chromosome
• Accession: NC_022222
• Organism: Staphylococcus aureus subsp. aureus 6850

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: RSAU_RS13940
• Protein ID: WP_011447039.1
• Coordinates: 664901..665077 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	665065..665239 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RSAU_RS03115	660136..663921	+	3786	WP_020977044.1	bacteriophage minor structural protein	-
RSAU_RS03120	663911..664063	+	153	WP_001153681.1	hypothetical protein	-
RSAU_RS03125	664110..664397	+	288	WP_001040261.1	hypothetical protein	-
RSAU_RS03130	664455..664751	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
RSAU_RS13940	664901..665077	+	177	WP_011447039.1	putative holin-like toxin	Toxin
-	665065..665239	-	175	-	-	Antitoxin
RSAU_RS03145	665289..665543	+	255	WP_000611512.1	phage holin	-
RSAU_RS03150	665555..666310	+	756	WP_000861038.1	CHAP domain-containing protein	-
RSAU_RS03155	666501..666992	+	492	WP_000920037.1	staphylokinase	-
RSAU_RS14530	667642..667977	+	336	Protein_599	SH3 domain-containing protein	-
RSAU_RS03165	668072..668522	-	451	Protein_600	chemotaxis-inhibiting protein CHIPS	-
RSAU_RS03170	669207..669557	+	351	WP_000702263.1	complement inhibitor SCIN-A	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sak / chp / chp / scn	645845..674892	29047
	-	flank	IS/Tn	-	-	669839..671485	1646

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T29949 WP_011447039.1 NC_022222:664901-665077 [Staphylococcus aureus subsp. aureus 6850]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T29949 NC_022222:664901-665077 [Staphylococcus aureus subsp. aureus 6850]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 175 bp

>AT29949 NC_022222:c665239-665065 [Staphylococcus aureus subsp. aureus 6850]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin