Detailed information of TA system TA029940

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-VapI
• Location: 699629..700218
• Replicon: chromosome
• Accession: NC_022198
• Organism: Corynebacterium argentoratense DSM 44202

Toxin (Protein)

• Gene name: graT
• Uniprot ID: -
• Locus tag: CARG_RS09820
• Protein ID: WP_081761598.1
• Coordinates: 699629..699910 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: CARG_RS03495
• Protein ID: WP_020976016.1
• Coordinates: 699919..700218 (+)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CARG_RS09815	694832..695089	+	258	WP_081761597.1	type II toxin-antitoxin system RelE/ParE family toxin	-
CARG_RS10045	695209..695304	-	96	Protein_667	transposase	-
CARG_RS03475	695331..696645	-	1315	Protein_668	ISL3 family transposase	-
CARG_RS03480	696930..698822	-	1893	WP_020976013.1	cadmium-translocating P-type ATPase	-
CARG_RS03485	698819..699178	-	360	WP_020976014.1	metalloregulator ArsR/SmtB family transcription factor	-
CARG_RS03490	699261..699374	-	114	WP_020976015.1	hypothetical protein	-
CARG_RS09820	699629..699910	+	282	WP_081761598.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CARG_RS03495	699919..700218	+	300	WP_020976016.1	HigA family addiction module antidote protein	Antitoxin
CARG_RS03500	700293..700589	-	297	WP_020976017.1	hypothetical protein	-
CARG_RS03505	700626..701585	-	960	WP_020976018.1	DUF808 domain-containing protein	-
CARG_RS09600	701586..702221	-	636	WP_169733197.1	DUF4232 domain-containing protein	-
CARG_RS03515	702416..703063	+	648	WP_020976020.1	ECF transporter S component	-
CARG_RS03520	703071..704669	+	1599	WP_020976021.1	ATP-binding cassette domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	695331..695594	263

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (2-93)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (7-83)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10739.23 Da
• Isoelectric Point: 10.2176

>T29940 WP_081761598.1 NC_022198:699629-699910 [Corynebacterium argentoratense DSM 44202]
VIRSFGNRDAELVWLREPAPKLDLRIHRVANRKLQLLDAATSLNSLRVSPGNRLEALKGDRKGQYSIRINSQWRICFNWT
EAGPENAIIEDYH

Nucleotide

• Length: 282 bp

>T29940 NC_022198:699629-699910 [Corynebacterium argentoratense DSM 44202]
GTGATCAGATCATTTGGTAACCGCGACGCGGAGCTTGTGTGGCTGCGCGAACCGGCTCCAAAGCTTGATCTAAGGATTCA
TAGAGTTGCTAATCGCAAGCTTCAGCTCCTGGACGCTGCAACCTCCTTGAATTCCCTGAGAGTTTCGCCGGGGAATCGGC
TTGAGGCTTTGAAAGGGGACCGAAAAGGTCAGTACAGTATACGGATCAACAGTCAATGGAGGATTTGTTTTAACTGGACT
GAGGCAGGCCCAGAGAACGCGATCATTGAGGATTATCATTAA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11187.92 Da
• Isoelectric Point: 6.2258

>AT29940 WP_020976016.1 NC_022198:699919-700218 [Corynebacterium argentoratense DSM 44202]
MAEKLYEPIHPGEVLMEDFIKGFGITQHKLAVDIEVPPRRINEIVHGKRAITADTALRLGRYFGIESQFWLNLQSRYDLE
KAQSAAAEQLDKIVPIVAA

Nucleotide

• Length: 300 bp

>AT29940 NC_022198:699919-700218 [Corynebacterium argentoratense DSM 44202]
ATGGCCGAAAAGTTATATGAGCCGATACATCCTGGTGAGGTTCTGATGGAGGATTTCATCAAAGGGTTTGGCATTACGCA
ACACAAACTGGCCGTTGATATTGAAGTGCCACCCCGCAGGATAAATGAAATCGTTCATGGCAAGCGCGCAATCACTGCGG
ATACCGCGCTTCGGTTAGGTCGTTATTTTGGGATCGAATCTCAGTTCTGGCTGAATCTTCAGAGTCGCTATGATCTGGAA
AAGGCCCAGAGTGCAGCAGCTGAGCAACTTGACAAAATCGTGCCTATCGTTGCTGCTTGA