Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2475641..2476164 Replicon chromosome
Accession NC_022113
Organism Staphylococcus aureus subsp. aureus 55/2053

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2W3LFI1
Locus tag SAAG_RS12550 Protein ID WP_000074047.1
Coordinates 2475641..2475907 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2S6D1W5
Locus tag SAAG_RS12555 Protein ID WP_000587617.1
Coordinates 2475907..2476164 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAAG_RS12530 2470851..2472038 - 1188 WP_000026190.1 MFS transporter -
SAAG_RS12535 2472432..2473208 - 777 WP_000072154.1 iron export ABC transporter permease subunit FetB -
SAAG_RS12540 2473201..2473863 - 663 WP_000923514.1 ATP-binding cassette domain-containing protein -
SAAG_RS12545 2474209..2475285 - 1077 WP_001076679.1 M42 family metallopeptidase -
SAAG_RS12550 2475641..2475907 - 267 WP_000074047.1 Txe/YoeB family addiction module toxin Toxin
SAAG_RS12555 2475907..2476164 - 258 WP_000587617.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SAAG_RS12565 2476524..2476979 + 456 WP_000732090.1 YehR family lipoprotein -
SAAG_RS12570 2477147..2478724 - 1578 WP_000143489.1 FMN-binding glutamate synthase family protein -
SAAG_RS12575 2478920..2479669 + 750 WP_000072447.1 CPBP family intramembrane metalloprotease -
SAAG_RS12580 2479893..2481086 - 1194 WP_000675407.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10662.26 Da        Isoelectric Point: 10.1384

>T29937 WP_000074047.1 NC_022113:c2475907-2475641 [Staphylococcus aureus subsp. aureus 55/2053]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRIVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T29937 NC_022113:c2475907-2475641 [Staphylococcus aureus subsp. aureus 55/2053]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCCTTTGAAAAATTAGAACCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGATCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9747.71 Da        Isoelectric Point: 4.1353

>AT29937 WP_000587617.1 NC_022113:c2476164-2475907 [Staphylococcus aureus subsp. aureus 55/2053]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT29937 NC_022113:c2476164-2475907 [Staphylococcus aureus subsp. aureus 55/2053]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAGTAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2W3LFI1

Antitoxin

Source ID Structure
AlphaFold DB A0A2S6D1W5

References