Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2419025..2419542 Replicon chromosome
Accession NC_022113
Organism Staphylococcus aureus subsp. aureus 55/2053

Toxin (Protein)


Gene name yoeB Uniprot ID A0A170NWK0
Locus tag SAAG_RS12245 Protein ID WP_000251928.1
Coordinates 2419025..2419291 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A166LMC5
Locus tag SAAG_RS12250 Protein ID WP_000584497.1
Coordinates 2419291..2419542 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAAG_RS12220 2414232..2414768 - 537 WP_000024292.1 GNAT family N-acetyltransferase -
SAAG_RS12225 2415236..2416060 - 825 WP_000594640.1 formate/nitrite transporter family protein -
SAAG_RS12230 2416263..2416445 - 183 WP_000079140.1 hypothetical protein -
SAAG_RS12235 2416532..2416999 - 468 WP_000153340.1 SRPBCC domain-containing protein -
SAAG_RS12240 2417185..2418732 - 1548 WP_000727771.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
SAAG_RS12245 2419025..2419291 - 267 WP_000251928.1 Txe/YoeB family addiction module toxin Toxin
SAAG_RS12250 2419291..2419542 - 252 WP_000584497.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SAAG_RS12255 2419706..2419806 - 101 Protein_2335 hypothetical protein -
SAAG_RS12260 2419813..2420412 - 600 WP_000162804.1 DsbA family protein -
SAAG_RS12265 2420431..2420793 - 363 WP_000819843.1 DUF4467 domain-containing protein -
SAAG_RS12270 2421048..2422298 + 1251 WP_001012237.1 FemA/FemB family glycyltransferase FmhA -
SAAG_RS12275 2422395..2423126 - 732 WP_000615467.1 amino acid ABC transporter ATP-binding protein -
SAAG_RS12280 2423123..2423842 - 720 WP_000479573.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10465.06 Da        Isoelectric Point: 10.1628

>T29934 WP_000251928.1 NC_022113:c2419291-2419025 [Staphylococcus aureus subsp. aureus 55/2053]
MVRLNITFSPQAFEDYKYFQQNDKKMVKKINELIKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T29934 NC_022113:c2419291-2419025 [Staphylococcus aureus subsp. aureus 55/2053]
ATGGTTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTAATTAAAAGTATTGACAGAAATGGTGCGTTGAAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9401.54 Da        Isoelectric Point: 4.3407

>AT29934 WP_000584497.1 NC_022113:c2419542-2419291 [Staphylococcus aureus subsp. aureus 55/2053]
MIIKNYSYARQNLKALMTKVNDDSDIVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTVTKD
IDV

Download         Length: 252 bp

>AT29934 NC_022113:c2419542-2419291 [Staphylococcus aureus subsp. aureus 55/2053]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATAGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAATCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTGTAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A170NWK0

Antitoxin

Source ID Structure
AlphaFold DB A0A166LMC5

References