Detailed information of TA system TA029927

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 1983070..1983377
• Replicon: chromosome
• Accession: NC_022113
• Organism: Staphylococcus aureus subsp. aureus 55/2053

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: SAAG_RS14555
• Protein ID: WP_011447039.1
• Coordinates: 1983201..1983377 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1983070..1983209 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAAG_RS09825	1978412..1978672	+	261	WP_001791826.1	hypothetical protein	-
SAAG_RS09830	1978725..1979075	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
SAAG_RS09835	1979758..1980207	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
SAAG_RS09840	1980302..1980636	-	335	Protein_1874	SH3 domain-containing protein	-
SAAG_RS09845	1981286..1981777	-	492	WP_000919350.1	staphylokinase	-
SAAG_RS09850	1981968..1982723	-	756	WP_000861038.1	CHAP domain-containing protein	-
SAAG_RS09855	1982735..1982989	-	255	WP_000611512.1	phage holin	-
SAAG_RS09860	1983041..1983148	+	108	WP_001791821.1	hypothetical protein	-
-	1983070..1983209	+	140	NuclAT_0	-	Antitoxin
-	1983070..1983209	+	140	NuclAT_0	-	Antitoxin
-	1983070..1983209	+	140	NuclAT_0	-	Antitoxin
-	1983070..1983209	+	140	NuclAT_0	-	Antitoxin
SAAG_RS14555	1983201..1983377	-	177	WP_011447039.1	putative holin-like toxin	Toxin
SAAG_RS09870	1983527..1983823	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
SAAG_RS09875	1983881..1984168	-	288	WP_001040261.1	hypothetical protein	-
SAAG_RS09880	1984215..1984367	-	153	WP_001153681.1	hypothetical protein	-
SAAG_RS09885	1984357..1988142	-	3786	WP_000582165.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	1978725..2034925	56200

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T29927 WP_011447039.1 NC_022113:c1983377-1983201 [Staphylococcus aureus subsp. aureus 55/2053]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T29927 NC_022113:c1983377-1983201 [Staphylococcus aureus subsp. aureus 55/2053]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT29927 NC_022113:1983070-1983209 [Staphylococcus aureus subsp. aureus 55/2053]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin