Detailed information of TA system TA029921

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 1888631..1889133
• Replicon: chromosome
• Accession: NC_022097
• Organism: Treponema pedis str. T A4

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: S6A4C3
• Locus tag: TPE_RS08645
• Protein ID: WP_020965624.1
• Coordinates: 1888873..1889133 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: TPE_RS08640
• Protein ID: WP_024465572.1
• Coordinates: 1888631..1888873 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TPE_RS08625	1884722..1886173	+	1452	WP_020965619.1	aminomethyl-transferring glycine dehydrogenase subunit GcvPB	-
TPE_RS08630	1886385..1886621	+	237	WP_020965621.1	exodeoxyribonuclease VII small subunit	-
TPE_RS08635	1886636..1888537	+	1902	WP_020965622.1	DNA mismatch repair endonuclease MutL	-
TPE_RS08640	1888631..1888873	+	243	WP_024465572.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
TPE_RS08645	1888873..1889133	+	261	WP_020965624.1	Txe/YoeB family addiction module toxin	Toxin
TPE_RS08650	1889124..1889537	-	414	WP_020965625.1	hypothetical protein	-
TPE_RS08655	1889541..1890926	-	1386	WP_020965626.1	thiosulfate sulfurtransferase	-
TPE_RS08660	1891043..1891870	-	828	WP_144299225.1	hypothetical protein	-
TPE_RS08665	1891930..1892397	-	468	WP_020965628.1	SsrA-binding protein SmpB	-
TPE_RS08670	1892527..1893246	+	720	WP_020965629.1	signal peptidase I	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (3-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10444.24 Da
• Isoelectric Point: 10.4076

>T29921 WP_020965624.1 NC_022097:1888873-1889133 [Treponema pedis str. T A4]
MWIIKYAKEAVRDSKKIERSNLKQTVINLIEILKINPFQNPPPYEKLLGDLTGKYSRRINIQHRLVYEVFENKNTVRILR
MWTHYE

Nucleotide

• Length: 261 bp

>T29921 NC_022097:1888873-1889133 [Treponema pedis str. T A4]
ATGTGGATAATAAAATATGCAAAGGAAGCTGTAAGGGACAGTAAAAAAATCGAGCGGTCAAACTTAAAACAAACTGTTAT
AAATTTAATTGAAATATTAAAAATAAATCCTTTCCAAAATCCTCCGCCTTATGAAAAATTACTAGGAGATTTGACCGGAA
AATATTCCAGAAGAATAAATATTCAACATCGTTTAGTTTATGAAGTTTTTGAAAATAAAAATACTGTTCGTATTCTTAGA
ATGTGGACACATTATGAATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9154.40 Da
• Isoelectric Point: 4.7571

>AT29921 WP_024465572.1 NC_022097:1888631-1888873 [Treponema pedis str. T A4]
MMVMTATQARSNLHTLIDKTKNFHEPIIISGKRHNAVLISEEDWNSIQETLYLYSVPGLRESIIEASKEPLENSIEDIGW

Nucleotide

• Length: 243 bp

>AT29921 NC_022097:1888631-1888873 [Treponema pedis str. T A4]
ATGATGGTAATGACGGCAACACAAGCTCGCAGTAATTTACATACGTTAATTGATAAGACAAAAAATTTTCATGAACCGAT
TATTATTTCAGGAAAAAGGCATAATGCCGTACTAATTTCGGAAGAAGACTGGAATTCAATTCAGGAAACTCTGTATTTAT
ATTCCGTTCCCGGACTTAGAGAATCTATTATAGAGGCAAGTAAAGAACCTTTGGAAAACAGTATTGAGGATATCGGCTGG
TAA

Structures

Toxin

• AlphaFold DB: S6A4C3