Detailed information of TA system TA029861

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 887900..888405
• Replicon: chromosome
• Accession: NC_021878
• Organism: Arcobacter butzleri 7h1h

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: S5P9X0
• Locus tag: A7H1H_RS04550
• Protein ID: WP_020847755.1
• Coordinates: 887900..888166 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: S5PBA8
• Locus tag: A7H1H_RS04555
• Protein ID: WP_020847756.1
• Coordinates: 888160..888405 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A7H1H_RS04525	883987..884352	-	366	WP_020847750.1	RidA family protein	-
A7H1H_RS04530	884421..884768	-	348	WP_020847751.1	hypothetical protein	-
A7H1H_RS04535	884778..885233	-	456	WP_020847752.1	hypothetical protein	-
A7H1H_RS04540	885321..887024	+	1704	WP_020847753.1	YdiU family protein	-
A7H1H_RS04545	887272..887613	-	342	WP_020847754.1	cupin domain-containing protein	-
A7H1H_RS04550	887900..888166	-	267	WP_020847755.1	Txe/YoeB family addiction module toxin	Toxin
A7H1H_RS04555	888160..888405	-	246	WP_020847756.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
A7H1H_RS04560	888628..889170	-	543	WP_020847757.1	hypothetical protein	-
A7H1H_RS04565	889304..890839	-	1536	WP_004509105.1	glutamine-hydrolyzing GMP synthase	-
A7H1H_RS04570	890904..892355	-	1452	WP_020847758.1	FAD-binding protein	-
A7H1H_RS04575	892454..892870	+	417	WP_014468566.1	DUF721 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-70)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10244.93 Da
• Isoelectric Point: 9.9946

>T29861 WP_020847755.1 NC_021878:c888166-887900 [Arcobacter butzleri 7h1h]
MVNYKLVYTKQAGKDAKKLSNSGLKSKALELLEIISQNPYQNPPPYEKLIGDLNSAISRRINIQHRLVYEVLEDIKTIKV
IRMWSHYE

Nucleotide

• Length: 267 bp

>T29861 NC_021878:c888166-887900 [Arcobacter butzleri 7h1h]
ATGGTAAACTATAAACTTGTTTACACTAAACAAGCCGGAAAAGATGCCAAGAAATTATCTAATTCAGGCTTAAAATCAAA
GGCTTTGGAACTATTAGAAATAATTTCTCAAAATCCATATCAAAATCCCCCGCCTTATGAAAAACTAATTGGTGATTTAA
ATAGTGCAATATCAAGAAGAATAAATATTCAACACAGATTAGTTTATGAAGTTTTAGAAGATATTAAAACTATAAAAGTA
ATACGAATGTGGTCACATTATGAGTAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9228.46 Da
• Isoelectric Point: 3.9417

>AT29861 WP_020847756.1 NC_021878:c888405-888160 [Arcobacter butzleri 7h1h]
MTKVMTVSQVRADIYNIIDETALTHEPIIITGKRTNAVMLSQEDWNAIQETLYLASIPNMRESIIEGLNTSIEDCDTELE
W

Nucleotide

• Length: 246 bp

>AT29861 NC_021878:c888405-888160 [Arcobacter butzleri 7h1h]
ATGACGAAAGTTATGACGGTTAGTCAAGTTCGAGCAGATATTTATAATATTATTGATGAAACAGCATTAACACATGAACC
AATAATTATAACTGGTAAAAGAACAAATGCTGTTATGTTATCTCAAGAAGATTGGAATGCCATCCAAGAAACTTTATATC
TAGCATCAATTCCAAATATGAGAGAATCTATAATTGAGGGATTAAATACATCTATTGAAGATTGTGATACAGAGTTAGAA
TGGTAA

Structures

Toxin

• AlphaFold DB: S5P9X0

Antitoxin

• AlphaFold DB: S5PBA8