Detailed information of TA system TA029813

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 15001..15658
• Replicon: plasmid unnamed
• Accession: NC_021815
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium var. 5-

Toxin (Protein)

• Gene name: higB
• Uniprot ID: U3PDC3
• Locus tag: CFSAN001921_RS23725
• Protein ID: WP_000270043.1
• Coordinates: 15308..15658 (-)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: CFSAN001921_RS23720
• Protein ID: WP_000124640.1
• Coordinates: 15001..15303 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CFSAN001921_RS23670	10624..11052	+	429	WP_000591074.1	hypothetical protein	-
CFSAN001921_RS23675	11109..11468	+	360	WP_000422768.1	hypothetical protein	-
CFSAN001921_RS23680	11468..11914	+	447	WP_000919345.1	Fe3+-siderophore ABC transporter permease	-
CFSAN001921_RS23685	11911..12429	+	519	WP_020833600.1	hypothetical protein	-
CFSAN001921_RS23690	12429..12659	+	231	WP_020833601.1	hypothetical protein	-
CFSAN001921_RS23695	12646..13503	+	858	WP_020833602.1	hypothetical protein	-
CFSAN001921_RS23705	13734..14261	+	528	WP_020833604.1	thermonuclease family protein	-
CFSAN001921_RS23710	14319..14591	+	273	WP_020833605.1	HU family DNA-binding protein	-
CFSAN001921_RS23715	14680..14973	+	294	WP_020833606.1	chromosome segregation protein ParM	-
CFSAN001921_RS23720	15001..15303	-	303	WP_000124640.1	XRE family transcriptional regulator	Antitoxin
CFSAN001921_RS23725	15308..15658	-	351	WP_000270043.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CFSAN001921_RS23730	15821..16369	+	549	WP_001061574.1	transcriptional regulator	-
CFSAN001921_RS23740	16710..16904	+	195	WP_000343597.1	hypothetical protein	-
CFSAN001921_RS23745	16912..17283	+	372	WP_020833608.1	hypothetical protein	-
CFSAN001921_RS23750	17276..17746	+	471	WP_001281821.1	hypothetical protein	-
CFSAN001921_RS23755	17755..18111	-	357	WP_020833609.1	hypothetical protein	-
CFSAN001921_RS23760	18208..18696	+	489	WP_001273096.1	DUF1643 domain-containing protein	-
CFSAN001921_RS23765	18699..19196	+	498	WP_000062185.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..221009	221009

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (12-65)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-123)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 17237.68 Da
• Isoelectric Point: 5.5500

>T29813 WP_000270043.1 NC_021815:c15658-15308 [Salmonella enterica subsp. enterica serovar Typhimurium var. 5-]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 351 bp

>T29813 NC_021815:c15658-15308 [Salmonella enterica subsp. enterica serovar Typhimurium var. 5-]
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Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 14882.85 Da
• Isoelectric Point: 5.5500

>AT29813 WP_000124640.1 NC_021815:c15303-15001 [Salmonella enterica subsp. enterica serovar Typhimurium var. 5-]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 303 bp

>AT29813 NC_021815:c15303-15001 [Salmonella enterica subsp. enterica serovar Typhimurium var. 5-]
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Structures

Toxin

• AlphaFold DB: A0A7G8AFB9