Detailed information of TA system TA029774

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 4188513..4189165
• Replicon: chromosome
• Accession: NC_021741
• Organism: Serratia liquefaciens ATCC 27592

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: M495_RS19610
• Protein ID: WP_020828410.1
• Coordinates: 4188513..4188857 (+)
• Length: 115 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A515CQP0
• Locus tag: M495_RS19615
• Protein ID: WP_020828411.1
• Coordinates: 4188863..4189165 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M495_RS19595	4185740..4186759	+	1020	WP_020828407.1	HTH-type transcriptional regulator GalR	-
M495_RS19600	4186756..4187211	-	456	WP_020828408.1	GNAT family N-acetyltransferase	-
M495_RS19605	4187363..4188373	+	1011	WP_020828409.1	LacI family DNA-binding transcriptional regulator	-
M495_RS19610	4188513..4188857	+	345	WP_020828410.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
M495_RS19615	4188863..4189165	+	303	WP_020828411.1	helix-turn-helix transcriptional regulator	Antitoxin
M495_RS19620	4189196..4190458	-	1263	WP_020828412.1	diaminopimelate decarboxylase	-
M495_RS19625	4190585..4191508	+	924	WP_020828413.1	LysR family transcriptional regulator	-
M495_RS19630	4191498..4192652	-	1155	WP_020828414.1	MFS transporter	-
M495_RS19635	4192970..4193878	-	909	WP_020828415.1	LysR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-106)

Antitoxin

• HigA2-like, helix-turn-helix domain (21-89)

Sequences

Toxin

Protein

• Length: 115 a.a.
• Molecular weight: 13522.63 Da
• Isoelectric Point: 10.8313

>T29774 WP_020828410.1 NC_021741:4188513-4188857 [Serratia liquefaciens ATCC 27592]
MWQIVTVERFDNWFLSLNSDQQKSVLVGIFKLQEFGPLLARPHADTLNHKNQIQHLKELRIQHRGRPFRIFFAFDPQRQA
VLLCGGDKTGNKRFYQQMLPIAVREFSHYLATQR

Nucleotide

• Length: 345 bp

>T29774 NC_021741:4188513-4188857 [Serratia liquefaciens ATCC 27592]
ATGTGGCAGATCGTGACCGTCGAACGATTCGACAACTGGTTTTTATCATTAAACAGCGATCAACAAAAAAGCGTGCTGGT
AGGAATATTCAAACTGCAGGAATTCGGCCCCTTGTTGGCGCGTCCTCATGCCGACACGCTGAATCACAAAAACCAAATAC
AGCATCTGAAAGAGTTACGTATTCAGCATCGCGGTCGGCCGTTTCGGATTTTCTTCGCCTTCGATCCGCAACGACAAGCG
GTCCTGCTTTGCGGTGGCGATAAAACCGGTAATAAACGCTTCTATCAACAAATGTTGCCGATCGCCGTCAGAGAGTTTTC
ACATTACTTGGCAACCCAGAGGTAA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11170.02 Da
• Isoelectric Point: 8.6182

>AT29774 WP_020828411.1 NC_021741:4188863-4189165 [Serratia liquefaciens ATCC 27592]
MAKPLSDLIDRLDPTVVEAAQQKADKEIFELRLAMLREELAVSQVELAKRLGISQPSVANLEKRGSEIKLSSLKRYIEAM
GGTLSLEVQLPNGQHRRMTL

Nucleotide

• Length: 303 bp

>AT29774 NC_021741:4188863-4189165 [Serratia liquefaciens ATCC 27592]
ATGGCCAAACCCTTATCAGATCTGATCGACAGACTCGATCCCACCGTAGTTGAAGCTGCGCAACAGAAAGCGGACAAAGA
AATTTTTGAACTGCGGCTGGCAATGCTTCGGGAAGAACTGGCGGTGTCTCAGGTGGAACTGGCCAAGCGGCTTGGTATCA
GCCAACCTTCGGTCGCCAACCTGGAAAAACGCGGCAGCGAAATTAAACTCTCTTCACTCAAACGCTATATCGAAGCCATG
GGGGGAACGCTGTCGCTGGAAGTTCAGCTCCCGAACGGCCAGCATCGACGGATGACGCTGTAA

Structures

Antitoxin

• AlphaFold DB: A0A515CQP0