Detailed information of TA system TA297242

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): DinJ-YafQ (relBE)/-
• Location: 3974203..3974741
• Replicon: chromosome
• Accession: UFRD01000002
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium strain NCTC12023

Toxin (Protein)

• Gene name: yafQ
• Uniprot ID: -
• Locus tag: NCTC12023_04196
• Protein ID: SUH99446.1
• Coordinates: 3974466..3974741 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: dinJ
• Uniprot ID: -
• Locus tag: NCTC12023_04195
• Protein ID: SUH99445.1
• Coordinates: 3974203..3974463 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NCTC12023_04192	3969956..3971509	+	1554	SUH99442.1	RNA-binding protein	-
NCTC12023_04193	3971854..3973071	+	1218	SUH99443.1	RtcB protein	-
NCTC12023_04194	3973075..3974094	+	1020	SUH99444.1	RNA 3'-terminal-phosphate cyclase	-
NCTC12023_04195	3974203..3974463	+	261	SUH99445.1	antitoxin	Antitoxin
NCTC12023_04196	3974466..3974741	+	276	SUH99446.1	putative cytoplasmic protein	Toxin
NCTC12023_04197	3974829..3977534	-	2706	SUH99447.1	HTH-type transcriptional regulator malT	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (4-91)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-84)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10739.34 Da
• Isoelectric Point: 8.8652

>T297242 SUH99446.1 UFRD01000002:3974466-3974741 [Salmonella enterica subsp. enterica serovar Typhimurium]
MGQREIEYSGQFQKDVKRAQKRHKDVGKLKTLMTLLIHHPFPLPAIYKDHPLQGSYSGYRDAHIEPDWILIYKITDECLR
FERTGTHADLF

Nucleotide

• Length: 276 bp

>T297242 UFRD01000002:3974466-3974741 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGAGCCTGACTGGATTCTTATTTATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9446.80 Da
• Isoelectric Point: 4.4734

>AT297242 SUH99445.1 UFRD01000002:3974203-3974463 [Salmonella enterica subsp. enterica serovar Typhimurium]
MAANALVRARIDETLKDQAADVLAEMGLTISDLIRITLTKVAREKALPFDLRIPNELTSRTIENSEAGVDIHKAKDADDL
FDQLGI

Nucleotide

• Length: 261 bp

>AT297242 UFRD01000002:3974203-3974463 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGCTGCAAATGCGCTTGTTCGTGCCCGTATCGACGAAACGCTGAAGGACCAGGCGGCAGATGTCCTGGCTGAAATGGG
GTTAACCATTTCTGATTTGATACGGATTACACTGACTAAAGTTGCGCGTGAAAAGGCATTGCCTTTTGATTTGCGCATAC
CCAATGAGTTAACGTCCCGAACGATAGAAAATAGCGAAGCTGGCGTTGATATTCATAAAGCCAAAGATGCTGATGATTTG
TTTGACCAGTTAGGGATCTGA