Detailed information of TA system TA297239

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/-
• Location: 3414372..3415126
• Replicon: chromosome
• Accession: UFRD01000002
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium strain NCTC12023

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: NCTC12023_03635
• Protein ID: SUH98924.1
• Coordinates: 3414372..3414683 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: NCTC12023_03636
• Protein ID: SUH98925.1
• Coordinates: 3414680..3415126 (+)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NCTC12023_03629	3410030..3410932	+	903	SUH98918.1	formate dehydrogenase-O subunit beta	-
NCTC12023_03630	3410929..3411564	+	636	SUH98919.1	formate dehydrogenase-O gamma subunit	-
NCTC12023_03631	3411561..3412490	+	930	SUH98920.1	FdhE protein	-
NCTC12023_03632	3412537..3412827	-	291	SUH98921.1	Cro/Cl family transcriptional regulator	-
NCTC12023_03633	3412828..3413139	-	312	SUH98922.1	Uncharacterised protein	-
NCTC12023_03634	3413357..3414286	+	930	SUH98923.1	lipase	-
NCTC12023_03635	3414372..3414683	+	312	SUH98924.1	cytoplasmic protein	Toxin
NCTC12023_03636	3414680..3415126	+	447	SUH98925.1	Antitoxin HigA	Antitoxin
NCTC12023_03637	3415141..3416082	-	942	SUH98926.1	acetyltransferase	-
NCTC12023_03638	3416127..3416564	-	438	SUH98927.1	D-tyrosyl-tRNA(Tyr) deacylase	-
NCTC12023_03639	3416561..3417340	-	780	SUH98928.1	ribonuclease BN	-
NCTC12023_03640	3417427..3418026	-	600	SUH98929.1	haloacid dehalogenase-like hydrolase	-
NCTC12023_03641	3418217..3419020	-	804	SUH98930.1	DeoR family transcriptional regulator	-
NCTC12023_03642	3419054..3419950	-	897	SUH98931.1	putative sugar kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, mRNA interferase HigB (21-93)

Antitoxin

• Cro/C1-type helix-turn-helix domain (93-146)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12432.40 Da
• Isoelectric Point: 9.5334

>T297239 SUH98924.1 UFRD01000002:3414372-3414683 [Salmonella enterica subsp. enterica serovar Typhimurium]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE

Nucleotide

• Length: 312 bp

>T297239 UFRD01000002:3414372-3414683 [Salmonella enterica subsp. enterica serovar Typhimurium]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATACTATCGGGGTAATAAAGAATGA

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16734.08 Da
• Isoelectric Point: 6.6451

>AT297239 SUH98925.1 UFRD01000002:3414680-3415126 [Salmonella enterica subsp. enterica serovar Typhimurium]
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Nucleotide

• Length: 447 bp

>AT297239 UFRD01000002:3414680-3415126 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAACCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTCAAACTACCAGCAGATGCCTTCATCGAGTAG