Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 3412537..3413139 Replicon chromosome
Accession UFRD01000002
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain NCTC12023

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NCTC12023_03633 Protein ID SUH98922.1
Coordinates 3412828..3413139 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NCTC12023_03632 Protein ID SUH98921.1
Coordinates 3412537..3412827 (-) Length 97 a.a.

Genomic Context

NCTC12023_03629NCTC12023_03630NCTC12023_03631NCTC12023_03634NCTC12023_03635NCTC12023_03636NCTC12023_03632NCTC12023_03633NCTC12023_03637NCTC12023_03638NCTC12023_03639NCTC12023_03640
Location: 3410030..3410932 (903 bp)
Type: Others
Protein ID: SUH98918.1
Location: 3410929..3411564 (636 bp)
Type: Others
Protein ID: SUH98919.1
Location: 3411561..3412490 (930 bp)
Type: Others
Protein ID: SUH98920.1
Location: 3413357..3414286 (930 bp)
Type: Others
Protein ID: SUH98923.1
Location: 3414372..3414683 (312 bp)
Type: Others
Protein ID: SUH98924.1
Location: 3414680..3415126 (447 bp)
Type: Others
Protein ID: SUH98925.1
Location: 3412537..3412827 (291 bp)
Type: Antitoxin
Protein ID: SUH98921.1
Location: 3412828..3413139 (312 bp)
Type: Toxin
Protein ID: SUH98922.1
Location: 3415141..3416082 (942 bp)
Type: Others
Protein ID: SUH98926.1
Location: 3416127..3416564 (438 bp)
Type: Others
Protein ID: SUH98927.1
Location: 3416561..3417340 (780 bp)
Type: Others
Protein ID: SUH98928.1
Location: 3417427..3418026 (600 bp)
Type: Others
Protein ID: SUH98929.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
NCTC12023_036293410030..3410932+903SUH98918.1formate dehydrogenase-O subunit beta-
NCTC12023_036303410929..3411564+636SUH98919.1formate dehydrogenase-O gamma subunit-
NCTC12023_036313411561..3412490+930SUH98920.1FdhE protein-
NCTC12023_036323412537..3412827-291SUH98921.1Cro/Cl family transcriptional regulatorAntitoxin
NCTC12023_036333412828..3413139-312SUH98922.1Uncharacterised proteinToxin
NCTC12023_036343413357..3414286+930SUH98923.1lipase-
NCTC12023_036353414372..3414683+312SUH98924.1cytoplasmic protein-
NCTC12023_036363414680..3415126+447SUH98925.1Antitoxin HigA-
NCTC12023_036373415141..3416082-942SUH98926.1acetyltransferase-
NCTC12023_036383416127..3416564-438SUH98927.1D-tyrosyl-tRNA(Tyr) deacylase-
NCTC12023_036393416561..3417340-780SUH98928.1ribonuclease BN-
NCTC12023_036403417427..3418026-600SUH98929.1haloacid dehalogenase-like hydrolase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T297238 SUH98922.1 UFRD01000002:c3413139-3412828 [Salmonella enterica subsp. enterica serovar Typhimurium]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

>T297238 UFRD01000002:c3413139-3412828 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT297238 SUH98921.1 UFRD01000002:c3412827-3412537 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp

>AT297238 UFRD01000002:c3412827-3412537 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAACCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAGC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References