Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ldrD-rdlD/Ldr(toxin)
Location 5086472..5086693 Replicon chromosome
Accession NZ_OY019088
Organism Escherichia coli O25b:H4-ST131 isolate 42

Toxin (Protein)


Gene name ldrD Uniprot ID A0A1U9U3P9
Locus tag QU406_RS24910 Protein ID WP_001531632.1
Coordinates 5086472..5086579 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name rdlD
Locus tag -
Coordinates 5086627..5086693 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QU406_RS24885 (5082316) 5082316..5083398 + 1083 WP_000804726.1 peptide chain release factor 1 -
QU406_RS24890 (5083398) 5083398..5084231 + 834 WP_000456450.1 peptide chain release factor N(5)-glutamine methyltransferase -
QU406_RS24895 (5084228) 5084228..5084620 + 393 WP_000200375.1 invasion regulator SirB2 -
QU406_RS24900 (5084624) 5084624..5085433 + 810 WP_001257044.1 invasion regulator SirB1 -
QU406_RS24905 (5085469) 5085469..5086323 + 855 WP_000811065.1 3-deoxy-8-phosphooctulonate synthase -
QU406_RS24910 (5086472) 5086472..5086579 - 108 WP_001531632.1 type I toxin-antitoxin system toxin Ldr family protein Toxin
- (5086629) 5086629..5086692 + 64 NuclAT_12 - -
- (5086629) 5086629..5086692 + 64 NuclAT_12 - -
- (5086629) 5086629..5086692 + 64 NuclAT_12 - -
- (5086629) 5086629..5086692 + 64 NuclAT_12 - -
- (5086629) 5086629..5086692 + 64 NuclAT_13 - -
- (5086629) 5086629..5086692 + 64 NuclAT_13 - -
- (5086629) 5086629..5086692 + 64 NuclAT_13 - -
- (5086629) 5086629..5086692 + 64 NuclAT_13 - -
- (5086629) 5086629..5086692 + 64 NuclAT_14 - -
- (5086629) 5086629..5086692 + 64 NuclAT_14 - -
- (5086629) 5086629..5086692 + 64 NuclAT_14 - -
- (5086629) 5086629..5086692 + 64 NuclAT_14 - -
- (5086629) 5086629..5086692 + 64 NuclAT_15 - -
- (5086629) 5086629..5086692 + 64 NuclAT_15 - -
- (5086629) 5086629..5086692 + 64 NuclAT_15 - -
- (5086629) 5086629..5086692 + 64 NuclAT_15 - -
- (5086629) 5086629..5086692 + 64 NuclAT_16 - -
- (5086629) 5086629..5086692 + 64 NuclAT_16 - -
- (5086629) 5086629..5086692 + 64 NuclAT_16 - -
- (5086629) 5086629..5086692 + 64 NuclAT_16 - -
- (5086629) 5086629..5086692 + 64 NuclAT_17 - -
- (5086629) 5086629..5086692 + 64 NuclAT_17 - -
- (5086629) 5086629..5086692 + 64 NuclAT_17 - -
- (5086629) 5086629..5086692 + 64 NuclAT_17 - -
- (5086627) 5086627..5086693 + 67 NuclAT_10 - Antitoxin
- (5086627) 5086627..5086693 + 67 NuclAT_10 - Antitoxin
- (5086627) 5086627..5086693 + 67 NuclAT_10 - Antitoxin
- (5086627) 5086627..5086693 + 67 NuclAT_10 - Antitoxin
- (5086627) 5086627..5086693 + 67 NuclAT_5 - Antitoxin
- (5086627) 5086627..5086693 + 67 NuclAT_5 - Antitoxin
- (5086627) 5086627..5086693 + 67 NuclAT_5 - Antitoxin
- (5086627) 5086627..5086693 + 67 NuclAT_5 - Antitoxin
- (5086627) 5086627..5086693 + 67 NuclAT_6 - Antitoxin
- (5086627) 5086627..5086693 + 67 NuclAT_6 - Antitoxin
- (5086627) 5086627..5086693 + 67 NuclAT_6 - Antitoxin
- (5086627) 5086627..5086693 + 67 NuclAT_6 - Antitoxin
- (5086627) 5086627..5086693 + 67 NuclAT_7 - Antitoxin
- (5086627) 5086627..5086693 + 67 NuclAT_7 - Antitoxin
- (5086627) 5086627..5086693 + 67 NuclAT_7 - Antitoxin
- (5086627) 5086627..5086693 + 67 NuclAT_7 - Antitoxin
- (5086627) 5086627..5086693 + 67 NuclAT_8 - Antitoxin
- (5086627) 5086627..5086693 + 67 NuclAT_8 - Antitoxin
- (5086627) 5086627..5086693 + 67 NuclAT_8 - Antitoxin
- (5086627) 5086627..5086693 + 67 NuclAT_8 - Antitoxin
- (5086627) 5086627..5086693 + 67 NuclAT_9 - Antitoxin
- (5086627) 5086627..5086693 + 67 NuclAT_9 - Antitoxin
- (5086627) 5086627..5086693 + 67 NuclAT_9 - Antitoxin
- (5086627) 5086627..5086693 + 67 NuclAT_9 - Antitoxin
- (5086629) 5086629..5086694 + 66 NuclAT_18 - -
- (5086629) 5086629..5086694 + 66 NuclAT_18 - -
- (5086629) 5086629..5086694 + 66 NuclAT_18 - -
- (5086629) 5086629..5086694 + 66 NuclAT_18 - -
- (5086629) 5086629..5086694 + 66 NuclAT_19 - -
- (5086629) 5086629..5086694 + 66 NuclAT_19 - -
- (5086629) 5086629..5086694 + 66 NuclAT_19 - -
- (5086629) 5086629..5086694 + 66 NuclAT_19 - -
- (5086629) 5086629..5086694 + 66 NuclAT_20 - -
- (5086629) 5086629..5086694 + 66 NuclAT_20 - -
- (5086629) 5086629..5086694 + 66 NuclAT_20 - -
- (5086629) 5086629..5086694 + 66 NuclAT_20 - -
- (5086629) 5086629..5086694 + 66 NuclAT_21 - -
- (5086629) 5086629..5086694 + 66 NuclAT_21 - -
- (5086629) 5086629..5086694 + 66 NuclAT_21 - -
- (5086629) 5086629..5086694 + 66 NuclAT_21 - -
- (5086629) 5086629..5086694 + 66 NuclAT_22 - -
- (5086629) 5086629..5086694 + 66 NuclAT_22 - -
- (5086629) 5086629..5086694 + 66 NuclAT_22 - -
- (5086629) 5086629..5086694 + 66 NuclAT_22 - -
- (5086629) 5086629..5086694 + 66 NuclAT_23 - -
- (5086629) 5086629..5086694 + 66 NuclAT_23 - -
- (5086629) 5086629..5086694 + 66 NuclAT_23 - -
- (5086629) 5086629..5086694 + 66 NuclAT_23 - -
QU406_RS24915 (5086984) 5086984..5088084 - 1101 WP_000063608.1 sodium-potassium/proton antiporter ChaA -
QU406_RS24920 (5088354) 5088354..5088593 + 240 WP_000120702.1 putative cation transport regulator ChaB -
QU406_RS24925 (5088742) 5088742..5089437 + 696 WP_001295621.1 glutathione-specific gamma-glutamylcyclotransferase -
QU406_RS24930 (5089481) 5089481..5089834 - 354 WP_001169659.1 DsrE/F sulfur relay family protein YchN -
QU406_RS24935 (5090019) 5090019..5091413 + 1395 WP_000086187.1 inverse autotransporter invasin YchO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4040.89 Da        Isoelectric Point: 12.5163

>T297214 WP_001531632.1 NZ_OY019088:c5086579-5086472 [Escherichia coli O25b:H4-ST131]
MTLAQFAMIFWHNLAAPILAGIITAVIVSWWRNRK

Download         Length: 108 bp

Antitoxin


Download         Length: 67 bp

>AT297214 NZ_OY019088:5086627-5086693 [Escherichia coli O25b:H4-ST131]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1U9U3P9

Antitoxin

Download structure file

References