Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 2929435..2930037 Replicon chromosome
Accession NZ_OY019088
Organism Escherichia coli O25b:H4-ST131 isolate 42

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag QU406_RS14315 Protein ID WP_000897302.1
Coordinates 2929435..2929746 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QU406_RS14320 Protein ID WP_000356397.1
Coordinates 2929747..2930037 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QU406_RS14290 (2925349) 2925349..2925948 + 600 WP_001296610.1 glucose-1-phosphatase -
QU406_RS14295 (2925942) 2925942..2926814 + 873 WP_000920762.1 virulence factor BrkB family protein -
QU406_RS14300 (2926811) 2926811..2927248 + 438 WP_000560981.1 D-aminoacyl-tRNA deacylase -
QU406_RS14305 (2927293) 2927293..2928234 + 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
QU406_RS14310 (2928298) 2928298..2929206 - 909 WP_001385591.1 alpha/beta hydrolase -
QU406_RS14315 (2929435) 2929435..2929746 + 312 WP_000897302.1 hypothetical protein Toxin
QU406_RS14320 (2929747) 2929747..2930037 + 291 WP_000356397.1 NadS family protein Antitoxin
QU406_RS14325 (2930122) 2930122..2930334 + 213 WP_000197774.1 hypothetical protein -
QU406_RS14330 (2930396) 2930396..2930674 + 279 WP_001296612.1 hypothetical protein -
QU406_RS14335 (2931071) 2931071..2931289 + 219 WP_001251293.1 CopG family transcriptional regulator -
QU406_RS14340 (2931474) 2931474..2932214 - 741 WP_000608806.1 hypothetical protein -
QU406_RS14345 (2932239) 2932239..2933087 - 849 WP_001038650.1 hypothetical protein -
QU406_RS14350 (2933377) 2933377..2933619 + 243 WP_001068514.1 CopG family transcriptional regulator -
QU406_RS14355 (2933801) 2933801..2934730 - 930 WP_000027696.1 formate dehydrogenase accessory protein FdhE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T297205 WP_000897302.1 NZ_OY019088:2929435-2929746 [Escherichia coli O25b:H4-ST131]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT297205 WP_000356397.1 NZ_OY019088:2929747-2930037 [Escherichia coli O25b:H4-ST131]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References