Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 831728..832230 Replicon chromosome
Accession NZ_OY019088
Organism Escherichia coli O25b:H4-ST131 isolate 42

Toxin (Protein)


Gene name yoeB Uniprot ID E2QNP2
Locus tag QU406_RS04355 Protein ID WP_000767819.1
Coordinates 831728..831982 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID E2QNP3
Locus tag QU406_RS04360 Protein ID WP_001259253.1
Coordinates 831979..832230 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QU406_RS04330 (827546) 827546..828004 - 459 WP_001531805.1 IS200/IS605-like element IS200C family transposase -
QU406_RS04335 (828221) 828221..829579 - 1359 WP_000019194.1 putrescine/proton symporter PlaP -
QU406_RS04340 (829569) 829569..829631 - 63 WP_010723108.1 membrane protein YoeI -
QU406_RS04345 (829846) 829846..830775 - 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
QU406_RS04350 (830821) 830821..831645 - 825 WP_000754737.1 SDR family oxidoreductase -
QU406_RS04355 (831728) 831728..831982 - 255 WP_000767819.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
QU406_RS04360 (831979) 831979..832230 - 252 WP_001259253.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
QU406_RS04365 (832513) 832513..832563 + 51 WP_001364200.1 his operon leader peptide -
QU406_RS04370 (832709) 832709..833608 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
QU406_RS04375 (833614) 833614..834918 + 1305 WP_001296211.1 histidinol dehydrogenase -
QU406_RS04380 (834915) 834915..835985 + 1071 WP_000108967.1 histidinol-phosphate transaminase -
QU406_RS04385 (835985) 835985..837052 + 1068 WP_000080057.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 827546..828004 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10110.53 Da        Isoelectric Point: 7.2749

>T297199 WP_000767819.1 NZ_OY019088:c831982-831728 [Escherichia coli O25b:H4-ST131]
VKLIWSEESWDDYLYWQEADKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHLLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9365.62 Da        Isoelectric Point: 4.6127

>AT297199 WP_001259253.1 NZ_OY019088:c832230-831979 [Escherichia coli O25b:H4-ST131]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSDKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E2QNP2

Antitoxin

Source ID Structure
AlphaFold DB E2QNP3

References