Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 110193..110788 Replicon chromosome
Accession NZ_OX638701
Organism Pseudomonas aeruginosa strain 4782MK isolate 4782MK

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag QSK41_RS00535 Protein ID WP_003113526.1
Coordinates 110510..110788 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QSK41_RS00530 Protein ID WP_003113527.1
Coordinates 110193..110498 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QSK41_RS00510 (PAER4782_00505) 105525..106244 + 720 WP_016264164.1 hypothetical protein -
QSK41_RS00515 (PAER4782_00510) 106305..108074 - 1770 WP_033970867.1 hypothetical protein -
QSK41_RS00520 108071..108547 - 477 WP_049873961.1 hypothetical protein -
QSK41_RS00525 (PAER4782_00515) 108544..109713 - 1170 WP_023129358.1 dsDNA nuclease domain-containing protein -
QSK41_RS00530 (PAER4782_00520) 110193..110498 - 306 WP_003113527.1 HigA family addiction module antitoxin Antitoxin
QSK41_RS00535 110510..110788 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QSK41_RS00540 110841..110969 - 129 Protein_105 integrase -
QSK41_RS00545 (PAER4782_00525) 111250..112005 - 756 WP_003298407.1 IS21-like element helper ATPase IstB -
QSK41_RS00550 (PAER4782_00530) 112023..113537 - 1515 WP_057391508.1 IS21 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 94657..113537 18880


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T297184 WP_003113526.1 NZ_OX638701:c110788-110510 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11247.81 Da        Isoelectric Point: 5.0747

>AT297184 WP_003113527.1 NZ_OX638701:c110498-110193 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMEFDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References