Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 1746646..1747241 Replicon chromosome
Accession NZ_OX638610
Organism Pseudomonas aeruginosa strain 3541 isolate 3541

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag QPK16_RS08050 Protein ID WP_003113526.1
Coordinates 1746646..1746924 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QPK16_RS08055 Protein ID WP_043096613.1
Coordinates 1746936..1747241 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QPK16_RS08030 (JCHGIK_09385) 1742071..1743309 + 1239 WP_023084819.1 C69 family dipeptidase -
QPK16_RS08035 (JCHGIK_09390) 1743371..1744018 + 648 WP_003095021.1 carbonate dehydratase -
QPK16_RS08040 (JCHGIK_09395) 1744089..1746317 - 2229 WP_043096614.1 TonB-dependent receptor -
QPK16_RS08045 1746465..1746593 + 129 Protein_1587 integrase -
QPK16_RS08050 1746646..1746924 + 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QPK16_RS08055 (JCHGIK_09400) 1746936..1747241 + 306 WP_043096613.1 HigA family addiction module antitoxin Antitoxin
QPK16_RS08065 (JCHGIK_09410) 1747647..1748747 - 1101 WP_003099270.1 redox-regulated ATPase YchF -
QPK16_RS08070 (JCHGIK_09415) 1748788..1749372 - 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
QPK16_RS08075 (JCHGIK_09420) 1749414..1750028 - 615 WP_003099279.1 50S ribosomal protein L25/general stress protein Ctc -
QPK16_RS08080 (JCHGIK_09425) 1750145..1751086 - 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
QPK16_RS08090 (JCHGIK_09435) 1751253..1752101 - 849 WP_003117426.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T297177 WP_003113526.1 NZ_OX638610:1746646-1746924 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11239.74 Da        Isoelectric Point: 4.4475

>AT297177 WP_043096613.1 NZ_OX638610:1746936-1747241 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMEFDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAQG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References