Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5963683..5964278 Replicon chromosome
Accession NZ_OX638564
Organism Pseudomonas aeruginosa strain 3796A isolate 3796A

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag QRQ54_RS27825 Protein ID WP_003113526.1
Coordinates 5964000..5964278 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QRQ54_RS27820 Protein ID WP_043096613.1
Coordinates 5963683..5963988 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRQ54_RS27785 (PAE3796A_27625) 5958823..5959671 + 849 WP_003117426.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
QRQ54_RS27795 (PAE3796A_27635) 5959838..5960779 + 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
QRQ54_RS27800 (PAE3796A_27640) 5960896..5961510 + 615 WP_003099279.1 50S ribosomal protein L25/general stress protein Ctc -
QRQ54_RS27805 (PAE3796A_27645) 5961552..5962136 + 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
QRQ54_RS27810 (PAE3796A_27650) 5962177..5963277 + 1101 WP_003099270.1 redox-regulated ATPase YchF -
QRQ54_RS27820 (PAE3796A_27660) 5963683..5963988 - 306 WP_043096613.1 HigA family addiction module antitoxin Antitoxin
QRQ54_RS27825 5964000..5964278 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QRQ54_RS27830 5964331..5964459 - 129 Protein_5503 integrase -
QRQ54_RS27835 (PAE3796A_27665) 5964607..5966835 + 2229 WP_043096614.1 TonB-dependent receptor -
QRQ54_RS27840 (PAE3796A_27670) 5966906..5967553 - 648 WP_003095021.1 carbonate dehydratase -
QRQ54_RS27845 (PAE3796A_27675) 5967615..5968853 - 1239 WP_023084819.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T297174 WP_003113526.1 NZ_OX638564:c5964278-5964000 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11239.74 Da        Isoelectric Point: 4.4475

>AT297174 WP_043096613.1 NZ_OX638564:c5963988-5963683 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMEFDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAQG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References