Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4975523..4976125 Replicon chromosome
Accession NZ_OX637964
Organism Escherichia coli O25b:H4-ST131 isolate 46

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag QQG90_RS24685 Protein ID WP_000897302.1
Coordinates 4975814..4976125 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QQG90_RS24680 Protein ID WP_000356397.1
Coordinates 4975523..4975813 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQG90_RS24650 (4970829) 4970829..4971758 + 930 WP_000027696.1 formate dehydrogenase accessory protein FdhE -
QQG90_RS24655 (4971940) 4971940..4972182 - 243 WP_001068514.1 CopG family transcriptional regulator -
QQG90_RS24660 (4972472) 4972472..4973320 + 849 WP_001038650.1 hypothetical protein -
QQG90_RS24665 (4973345) 4973345..4974085 + 741 WP_000608806.1 hypothetical protein -
QQG90_RS24670 (4974270) 4974270..4974488 - 219 WP_001251293.1 CopG family transcriptional regulator -
QQG90_RS24675 (4974886) 4974886..4975164 - 279 WP_001296612.1 hypothetical protein -
QQG90_RS24680 (4975523) 4975523..4975813 - 291 WP_000356397.1 NadS family protein Antitoxin
QQG90_RS24685 (4975814) 4975814..4976125 - 312 WP_000897302.1 hypothetical protein Toxin
QQG90_RS24690 (4976354) 4976354..4977262 + 909 WP_001385591.1 alpha/beta hydrolase -
QQG90_RS24695 (4977326) 4977326..4978267 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
QQG90_RS24700 (4978312) 4978312..4978749 - 438 WP_000560981.1 D-aminoacyl-tRNA deacylase -
QQG90_RS24705 (4978746) 4978746..4979618 - 873 WP_000920762.1 virulence factor BrkB family protein -
QQG90_RS24710 (4979612) 4979612..4980211 - 600 WP_001296610.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T297160 WP_000897302.1 NZ_OX637964:c4976125-4975814 [Escherichia coli O25b:H4-ST131]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT297160 WP_000356397.1 NZ_OX637964:c4975813-4975523 [Escherichia coli O25b:H4-ST131]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References